Nanotechnology-Based Techniques for Hair Follicle Regeneration

November 2023 in “ Biomaterials ”

Mafalda Correia, Joana Lopes, Daniela Lopes, Ana Melero, Pooyan Makvandi, Francisco Veiga, Jorge F. J. Coelho, Ana Fonseca, Ana Cláudia Paiva‐Santos

TLDR Nanotechnology could improve hair regrowth but faces challenges like complexity and safety concerns.

The document discusses the potential of nanotechnology-based techniques in hair follicle regeneration and hair loss treatment. It reviews current treatments like drug therapies, hair transplantation, low-level laser therapy, platelet-rich plasma, and stem cell therapies, and highlights their limitations. Nanotechnology, particularly nanoparticles, offers targeted therapy, controlled drug release, and reduced systemic toxicity. Techniques include microneedles, exogenous stimulation, and tissue engineering. Nanoparticles, including polymeric, lipid, and metallic ones, are seen as promising for drug delivery to hair follicles. The document also discusses the use of nanostructured lipid carriers, stem cell-derived extracellular vesicles, and nanofibers for hair follicle regeneration. However, challenges such as preparation complexity, scale-up reproducibility, regulatory approval, cost-effectiveness, quality, and safety concerns need to be addressed before clinical implementation.

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10 / 10 results

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