Hair Follicle Targeting and Dermal Drug Delivery with Curcumin Drug Nanocrystals: Essential Influence of Excipients

The document from November 23, 2020, discusses the use of nanocrystals to improve the delivery and efficacy of poorly soluble active pharmaceutical ingredients (API) for dermal applications. It highlights that while nanocrystals have been successful in enhancing oral bioavailability, their use in topical treatments is newer. The study conducted showed that excipients, even in small quantities, significantly influence the penetration and targeting of curcumin nanocrystals in the skin. Specifically, 2% ethanol was found to enhance hair follicle targeting and reduce passive diffusion, glycerol had the opposite effect, and propylene glycol promoted both pathways. The findings suggest that the selection of the appropriate excipient is crucial for the effective formulation of nanocrystals in dermal drug delivery, allowing control over whether the API is delivered through passive diffusion or as a drug reservoir in the hair follicles.