Hair Follicle Targeting With Curcumin Nanocrystals: Influence of Formulation Properties on Penetration Efficacy

    October 2020 in “ Journal of Controlled Release ”
    Olga Pelikh, Ralph W. Eckert, Shashank Reddy Pinnapireddy, Cornelia M. Keck
    Studysummary This study found that curcumin nanocrystals efficiently penetrated hair follicles down to the lower infundibulum in an ex-vivo pig ear model, regardless of the gel vehicle used, though passive dermal penetration varied with the vehicle’s skin hydrating properties.
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    Research cited in this study 8

    1. Effects of Turmeric (Curcuma Longa) on Skin Health: A Systematic Review of the Clinical Evidence Phytotherapy Research · 2016
    2. Polymeric Nanoparticles-Embedded Organogel for Roxithromycin Delivery to Hair Follicles European Journal of Pharmaceutics and Biopharmaceutics · 2014
    3. Comparison of Two Encapsulated Curcumin Systems in Different Formulations for In Vitro Skin Penetration Skin Research and Technology · 2012
    4. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    5. Hair Follicles, Their Disorders, and Their Opportunities Drug Discovery Today: Disease Mechanisms · 2008
    6. Innovative Liposomes as a Transfollicular Drug Delivery System: Penetration into Porcine Hair Follicles Journal of Investigative Dermatology · 2006
    7. Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    8. Treatments for Androgenetic Alopecia and Alopecia Areata Drugs · 2001