Particle Size Effect of Curcumin Nanocrystals on Transdermal and Transfollicular Penetration by Hyaluronic Acid-Dissolving Microneedle Delivery

    February 2022 in “ Pharmaceuticals ”
    Hong Xiang, Sai Xu, Jingyuan Li, Shihui Pan, Xiao Miao
    TLDR Smaller curcumin nanocrystals penetrate skin and hair follicles better than larger ones.
    The study investigated the impact of curcumin nanocrystals (CUR-NCs) particle size on transdermal and transfollicular penetration using a hyaluronic acid-dissolving microneedle delivery system. Three sizes of CUR-NCs (60 nm, 120 nm, and 480 nm) were used. Results showed that smaller CUR-NCs (60 nm) penetrated the skin and hair follicles more effectively than larger ones. The cumulative curcumin released from the microneedles was about two-fold higher than that of a curcumin gel after 48 hours. The study concluded that microneedles can effectively deliver hydrophobic drugs in a nanocrystal formulation, overcoming the skin barrier and delivering nanocrystals directly into the skin, forming multi-nanodrug reservoirs.
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