Polymeric Nanoparticles-Based Topical Delivery Systems for the Treatment of Dermatological Diseases

The document discussed the potential of polymeric nanoparticles-based topical delivery systems for treating dermatological diseases like psoriasis, contact dermatitis, and skin cancer. It reviewed various nanoparticles made from natural polymers such as chitosan, synthetic degradable polymers like aliphatic polyesters, and nondegradable polymers such as polyacrylates, with a focus on tyrosine-derived nanospheres (TyroSpheres™). These systems combined the benefits of nanosized drug carriers and topical application, showing promise for skin disease treatment. Future perspectives included the penetration of ultra-small nanoparticles (smaller than 40 nm) into skin layers, targeted drug delivery to hair follicle stem cells, and combining nanoparticles with microneedle arrays for applications like vaccine delivery.