Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles
July 2004
in “
Journal of controlled release
”
TLDR Smaller nanoparticles improve minoxidil absorption through hair follicles.
Researchers synthesized a biodegradable block copolymer, poly(ε-caprolactone)-block-poly(ethylene glycol), to create nanoparticles encapsulating minoxidil. These nanoparticles, sized at 40 and 130 nm, effectively delivered minoxidil to the skin, primarily through hair follicles. The study found that smaller nanoparticles enhanced the permeation behavior, suggesting that nanoparticle size plays a crucial role in the efficiency of transdermal drug delivery.
