Transdermal Delivery of Minoxidil with Block Copolymer Nanoparticles

July 2004 in “ Journal of controlled release ”

Jongwon Shim, H SEOKKANG, W PARK, Song Han, J KIM, I CHANG

minoxidil nanoparticles skin penetration epidermal layer receptor solution phospholipid liposomes ethanol–water admixture hair follicles confocal microscopy Rogaine nanoparticles skin absorption epidermis receptor solution liposomes ethanol-water mixture hair follicles confocal microscopy

TLDR Smaller nanoparticles improve minoxidil absorption through hair follicles.

Researchers synthesized a biodegradable block copolymer, poly(ε-caprolactone)-block-poly(ethylene glycol), to create nanoparticles encapsulating minoxidil. These nanoparticles, sized at 40 and 130 nm, effectively delivered minoxidil to the skin, primarily through hair follicles. The study found that smaller nanoparticles enhanced the permeation behavior, suggesting that nanoparticle size plays a crucial role in the efficiency of transdermal drug delivery.

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research Minoxidil Sulfotransferase Enzymatical Activity in Plants: A Novel Paradigm in Increasing Minoxidil Response in Androgenetic Alopecia

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