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New in community
- Featured Community Post
Research Backed Dutasteride Simulator (Serum/scalp DHT included for all doses)
A Dutasteride Simulator predicts serum dutasteride, serum DHT, and scalp DHT levels using models from research papers. It simulates various dosing schedules to determine steady-state effects and visualizes outcomes, including hair growth-related scalp DHT suppression.
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Is this the 2026 Hairloss Nuclear Stack?
Finasteride/Dutasteride A user discusses their extensive hair loss treatment regimen, which includes dutasteride, oral and topical minoxidil, RU58841, various supplements, and lifestyle changes. The conversation includes opinions on the effectiveness and necessity of such a comprehensive approach, with some users suggesting alternatives like microneedling and questioning the high dosage of dutasteride. -
3 month update finasteride 1mg daily no minoxidil
Progress Pictures A mid-40s male experienced significant hair loss after weight loss, tried minoxidil with no success, then started 1mg finasteride daily, resulting in reduced hair loss and thicker hair in three months. Users expressed amazement and inquired about side effects and improvement timeline. -
Officially a year on Dutasteride, and I’ve still lost ground
Treatments A 26-year-old has been using Dutasteride and Minoxidil for nearly a year but continues to experience hair loss. They are seeking suggestions for other treatments or considering a hair transplant. -
Clascoterone - what we have right now
Research/Science Clascoterone is a topical treatment for androgenetic alopecia, showing modest to moderate hair regrowth, and may be available by 2027-2028. It is considered safer than finasteride, with discussions on its effectiveness compared to RU58841 and pyrilutamide. -
When is the cure gonna drop , how much more time
Research/Science There is no imminent cure for hair loss, but treatments like Minoxidil, Finasteride, and new drugs such as KX-826, GT-20029, and PP405 are being explored. Current solutions focus on slowing hair loss and stimulating growth, with hopes for better options in the future. -
Should i go on treatment
Treatments The user is considering starting a 6-month treatment with minoxidil and finasteride for hair loss but is unsure due to minimal current hair loss and concerns about mental health effects from oral finasteride. They are uncertain about the correct application areas for these treatments.
New Featured Research
A SIBO-mediated aetiology for a subset of Post-Finasteride Syndrome cases: investigating gut-derived toxins
This theoretical paper suggests a novel gut-centric cause for a subset of Post-Finasteride Syndrome (PFS) cases, which are not fully explained by androgen deprivation. It hypothesizes that a chronic overgrowth of hydrogen sulphide (H₂S)-producing bacteria in the small intestine acts as a systemic mitochondrial toxin. This condition may create a dysbiotic feedback loop that perpetuates the epigenetic silencing initially triggered by finasteride exposure. The paper proposes that this acquired metabolic dysfunction, driven by gut-derived toxins, could explain the persistence of PFS symptoms and highlights the small intestinal microbiome as a potential therapeutic target.
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New in research
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Androgenetic Alopecia in Women: A Narrative Review of Pathophysiology, Clinical Evaluation, and Treatments
Spironolactone is effective for treating female hair loss, with new treatments like clascoterone showing promise.
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A SIBO-Mediated Etiology for a Subset of Post-Finasteride Syndrome Cases: Investigating Gut-Derived Toxins
Gut bacteria overgrowth may cause some Post-Finasteride Syndrome symptoms.
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The N-K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns Using N-K Universal Computer
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
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The N-K Healing Series: Complete Geometric Restoration for Wounds, Pain, and Burns Using N-K Universal Computer
N-K Geometric Medicine heals wounds, pain, and burns better and faster than current treatments, without side effects.
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Targeting the Gut Microbiota with Probiotics and Postbiotics: Emerging Strategies Against Alopecia
Modifying gut bacteria with pro- and postbiotics may help treat hair loss.
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Development and Evaluation of a Niosome-Integrated Microneedle System for Targeted Follicular Delivery of Ketoconazole in Alopecia Therapy
The new microneedle system improves hair growth in alopecia treatment.
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Effect of Platelet-Rich Plasma on Hair Follicle Growth in C57BL/6 Mice
Platelet-rich plasma (PRP) speeds up hair growth in mice.
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Significant Improvement With Ivarmacitinib After Suboptimal Response to Tofacitinib in Severe Alopecia Areata: A Case Report and Literature Review
Ivarmacitinib significantly improved hair regrowth in severe alopecia areata after tofacitinib was less effective.
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Comparative Efficacy of Oral Dutasteride and Low, Medium, and High-Dose Oral Minoxidil: A Six-Month Prospective Trichoscopic and Clinical Study
Oral minoxidil improved hair loss more than oral dutasteride.