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- Featured Community Post
FCE 28260: A Forgotten 5α-Reductase Inhibition
FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.
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If dutesteride and oral minoxidil doesn’t work that’s it right?
Treatment A user is experiencing ongoing hair loss despite using 0.5mg dutasteride and 2.5mg oral minoxidil for several years and is seeking advice. Suggestions include ensuring correct diagnosis, checking for other health issues, considering finasteride, trying topical antiandrogens, and consulting a dermatologist. -
2nd month update, my workmates said it looks better
Progress Pictures The user is taking generic oral dutasteride, oral minoxidil, vitamin D, and uses daily shampoo, along with a healthy diet and regular gym exercise for hair loss. Workmates noticed improvement in the user's hair condition. -
Has anyone ever had success with just micro-needling?
Microneedling People are discussing if microneedling alone can improve hair loss without using treatments like minoxidil, finasteride, or RU58841. Some users report moderate success with microneedling and natural remedies, but most suggest that results are better when combined with medical treatments. -
Fin losing effect after 7 months?
Finasteride/Dutasteride Mooseman1944 noticed hair regrowth and less shedding during the first 6 months of taking finasteride, but is now experiencing increased shedding and thinning hair. They are considering switching to dutasteride or adding minoxidil if there's no improvement by next August. -
Progression or regression? One year of oral Fin (1mg daily) x oral Min (2.5mg daily)
Progress Pictures The user has been taking oral finasteride (1mg daily) and oral minoxidil (2.5mg daily) for about a year to treat hair loss and is unsure about the progress, considering switching to dutasteride and increasing the minoxidil dose. Photos were shared for comparison, and another user suggested continuing the current treatment unless the condition worsens. -
Breaking hair loss news! GT20029 is a resounding success!
Product GT20029, a new hair loss treatment, shows promising results but only a slight improvement over placebo. People are cautiously optimistic, discussing its potential and combining it with existing treatments like Minoxidil and Finasteride. -
2 months of 1mg Finasteride daily , %5 minoxidil 2x daily, Nizoral Shampoo and 1.5mm depth microneedling weekly
Progress Pictures A user shared progress pictures after using 1mg Finasteride daily, 5% Minoxidil twice daily, Nizoral Shampoo, and weekly microneedling at 1.5mm depth for two months, reporting no side effects and discussing their routine and supplements. Commenters reacted positively, with one advising caution with creatine and another endorsing the benefits of microneedling.
Review of: "“Toupee or not Toupee?” Sic (et Non). Social perceptions of Male Pattern Baldness (Androgenetic Alopecia)"
The review of the paper "Toupee or not Toupee?" highlights several areas for improvement. The reviewer suggests that the study needs to provide more information about the sample size used to ensure statistical significance and representativeness. The generalizability of the findings beyond the specific sample used in the research should also be considered. The methodology section needs more detail for a comprehensive understanding of how judgments were collected and analyzed. The study should address potential biases, including cultural or personal preferences of judges. Lastly, the paper should discuss any ethical considerations related to using individuals as stimuli for attractiveness judgments and other traits.
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New in research
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Persistent Gynecomastia due to Short-term Low-dose Finasteride for Androgenetic Alopecia
A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.
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Novel variant in <i>WNT10A</i> caused short anagen hair syndrome in a Chinese pedigree
A new change in the WNT10A gene caused a condition leading to short hair growth in a Chinese family.
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Impact of Hair Damage on the Penetration Profile of Coconut, Avocado, and Argan Oils into Caucasian Hair Fibers
Different oils affect hair flexibility and strength, with their impact varying on whether hair is virgin or bleached.
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Efficacy of topical minoxidil in enhancing beard growth in a group of transgender assigned female at birth individuals on gender affirming hormone therapy
Topical minoxidil helps transgender individuals assigned female at birth grow more facial hair.
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Platelet‐rich fibrin: A review of its role as a new treatment in androgenetic alopecia
Platelet-rich fibrin might be a promising treatment for hair loss, but more research is needed to confirm its effectiveness.
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Hair Regeneration in Androgenetic Alopecia using Secretome of Adipose-derived Stem Cells (ADSC) and Minoxidil: A Comparative Study of Three Groups
The combination of ADSC secretome and minoxidil was most effective for hair growth in people with hair loss.
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Comparison of the Efficacy of Two Different Local Anesthesia Techniques for Mesotherapy in Temporal Region Alopecia
Adding a zygomaticotemporal nerve block reduces pain more effectively during hair regrowth treatments.
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799 A Single Center Retrospective Cohort Study of Burn Scar Alopecia Surgery
Surgery for burn scar alopecia often involves multiple procedures, and treatment options should be more accessible to improve self-image.
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Lasers in the management of alopecia: a review of established therapies and advances in treatment
Lasers and light therapies are effective in promoting hair regrowth for different types of hair loss.