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    New Featured Research

    Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology

    This study explores how mesenchymal and epithelial stem cells in hair follicles coordinate hair regeneration and how these processes change with aging and androgenetic alopecia (AGA). The researchers used a spatiotemporal atlas and functional validation to understand these dynamics. They found that aging leads to a passive depletion of regenerative signals from human dermal sheath cells (hDSC), while AGA causes hDSC to shift towards inhibitory signaling, impairing hair follicle stem cell (HFSC) function. The study identifies hDSC-secreted pleiotrophin (PTN) as a crucial factor that promotes hair growth and counteracts the growth suppression caused by androgens. This research provides a comprehensive framework for understanding stem cell interactions in hair follicle aging and pathology, offering insights for restoring tissue regeneration.

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    1. Integrated Evaluation of Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Across Skin-Related Cellular and Zebrafish Models

      This study found that human umbilical cord mesenchymal stromal cell-derived extracellular vesicles improved several skin-related processes, including reducing oxidative injury, enhancing wound repair, and modulating androgen-related responses, in various cellular and zebrafish models.

    2. The Hyperandrogenism in Female Athletes: When Dermatological Signs Become an Endocrine and Sports Medicine Challenge

      This review discusses hyperandrogenism in female athletes, focusing on dermatological indicators for diagnosis and emphasizing the need for a multidisciplinary approach to manage the condition effectively.

    3. Graft Survival by Norwood-Hamilton Stage: A Stratified Outcome Analysis of Follicular Unit Extraction Patients at Vera Clinic (2020–2025)

      This study found that graft survival rates after follicular unit extraction varied significantly across different stages of androgenetic alopecia, suggesting the NH stage may influence surgical outcomes.

    4. Development of Collagen-Like Peptide Hydrogel Biomaterials for Soft Tissue Repair

      This study suggests that peptide-based hydrogels are a promising platform for repairing soft tissue in the skin, cornea, and heart, demonstrating benefits in wound healing and myocardial infarction in a mouse model.

    5. Prevalence of Metabolic Syndrome in Patients With Androgenetic Alopecia: An Analysis of Current Evidence

      This study found that metabolic syndrome and several metabolic abnormalities are common among patients with androgenetic alopecia, with prevalence estimates varying significantly across different studies.

    6. GCN5-Mediated H3K27cr Regulates Hair Follicle Stem Cell Migration and Hair Follicle Development Through KRT80 Activation

      This study found that GCN5-mediated H3K27 crotonylation targets KRT80 in cashmere goats, promoting secondary hair follicle stem cell migration during hair follicle development.

    7. Editorial: Update in Trichology and Hair Transplantation

      This review explores contemporary trichology, focusing on advanced diagnostic methods and treatment strategies for hair and scalp disorders, but it reports no new clinical results and calls for more evidence-based studies.

    8. Low-Dose Oral Versus Topical Minoxidil in Androgenetic Alopecia: A Randomized, Double-Blind, Double-Dummy Controlled Trial

      This randomized controlled trial found that both topical and low-dose oral minoxidil improved androgenetic alopecia, but did not establish non-inferiority or equivalence between the treatments.

    9. Beyond Hirsutism: Hair Phenotypes as Clinical Signals for the Recognition of Polyendocrine Metabolic Ovarian Syndrome: A Scoping Review Protocol

      This review discusses the potential of integrated hair phenotypes as clinical signals for recognizing the recently renamed PMOS (formerly PCOS) and reports no new results; the authors emphasize the need for systematic mapping.
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    New in community

    1. 5 month results on oral finasteride and topical minoxidil

      The poster shares progress photos on oral finasteride, topical minoxidil and microneedling, and mentions plans for a hair transplant. Commenters react, with one suggesting adding tretinoin.

    2. Ive taken finasteride for 4.5 years, heres my experience

      The poster shares their long-term experience on finasteride, describing side effects and changes in their hair, and asks whether others had similar experiences or better luck with topical options. Commenters disagree about the cause of the side effects and suggest alternatives such as topical finasteride and dutasteride.

    3. Be very careful what you wish for!

      The poster shares their experience with a regimen of dutasteride, oral minoxidil and ketoconazole shampoo, including shedding and progress. Commenters ask questions about side effects and their routine and share their own experiences.

    4. 9 month results on fin/min chewable

      The poster shares progress photos while using a finasteride and minoxidil chewable along with scalp massage and ketoconazole shampoo. Commenters respond with encouragement and questions.

    5. 24m, I am planning to get a hair transplant at Asmed

      The poster asks for opinions on a planned hair transplant at the Asmed clinic, including their suitability and what to expect. Commenters discuss trying finasteride, minoxidil or dutasteride before surgery and question the clinic's reputation.

    6. In Response to the Kid who Posted that Anything Other than NW0 is cope, I’m Posting to Remind You That NW2 is an Elite Hairline

      The poster argues that an NW2 hairline is ideal, including for hair transplants, and that conservative placement looks more natural. Commenters debate Norwood classifications and the importance of density over hairline position.

    7. My 7 month results so far from 0.9% KX-826

      The poster shares progress photos on KX-826 alongside minoxidil and describes their routine. Commenters ask questions about dosing, sourcing, shedding and combining it with other treatments.

    8. Oral minox gave me wizard eyebrows

      The poster shares a photo of eyebrow changes while taking oral minoxidil. Commenters react and share their own experiences with similar eyebrow growth.

    9. 28M | 4.5 months on minoxidil | My hair-loss journey Hi everyone, my name is Ayush and I'm 28 years old. I've been noticing hair shedding/hair loss since around 2020. At that time, I kept telling myself, “I still have enough hair, it's not that bad.” So I basically did nothing about it till 2026 may

      The poster shares progress photos while on minoxidil and asks for opinions on adding finasteride. Commenters discuss adding finasteride or dutasteride, with differing views.
    View more new posts in Community →