research MLO-Mediated Ca2+ Influx Regulates Root Hair Tip Growth in Arabidopsis
MLO proteins are crucial for root hair growth by regulating calcium and ROS levels.
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30 / 1000+ resultsresearch Formulation and Evaluation of Polyherbal Shampoo to Promote Hair Growth and Provide Antidandruff Action Using Polyherbal Extract
The polyherbal shampoo effectively promotes hair growth and reduces dandruff.
research Randomized controlled trial on the efficacy and safety of the combination therapy of topical 0.1% finasteride − 5% Minoxidil in male androgenetic alopecia
This study evaluated the efficacy and safety of a combination therapy of topical 0.1% finasteride and 5% minoxidil for male androgenetic alopecia over 12 weeks, involving 40 subjects. The combination therapy showed significant improvements in hair density, diameter, and terminal hair rate, similar to the control group using only 5% minoxidil, with no significant differences between the groups. Systemic side effects included libido reduction in the control group and mild erectile dysfunction and chest pain in the treatment group. Local side effects like itching, shedding, and dandruff were similar across groups, with one case of contact dermatitis in the treatment group. Overall, the combination therapy was as safe and effective as minoxidil alone in increasing hair density and diameter.
research Approach to the Patient: Hirsutism
Hirsutism affects many women and is managed with a combination of medical treatments and hair removal, tailored to individual needs.
research Association Between Androgenic Alopecia and Schizophrenia: A Bidirectional Mendelian Randomization Study
The study investigated the causal relationship between androgenetic alopecia (AGA) and schizophrenia using a bidirectional Mendelian randomization analysis. The forward MR analysis found a significant causal relationship between AGA and schizophrenia, with an odds ratio of 0.996 (95% CI: 0.992–0.999; P = 0.025). However, the reverse MR analysis showed no causal association between schizophrenia and AGA, with an odds ratio of 1.061 (95% CI: 0.965–1.165; P = 0.220). No heterogeneity or pleiotropy was observed in the analyses. Gene ontology and KEGG pathway analyses suggested that genes at SNP sites in the forward MR analysis were linked to various metabolic processes and signaling pathways. The study concludes that AGA may causally influence schizophrenia, but not vice versa.
research Recent Advances in Drug Development for Hair Loss
New treatments for hair loss show promise with advanced therapies and better targeting.
research The Urologic Impact of Long-Term Finasteride-1 Mg Use for Androgenic Alopecia: A Matched-Cohort Database Analysis
Long-term finasteride use may lower prostate cancer risk but increase the need for erectile dysfunction medication.
research Effect of Microneedling with Growth Factors and Low-Level Light Therapy on Trichotillomania Treatment
The combined therapy of microneedling and light therapy effectively and safely promotes hair regrowth in trichotillomania.
research Real-World Effectiveness and Safety of Janus Kinase Inhibitors in Alopecia Areata: A Retrospective Cohort Study of 72 Patients
Janus Kinase inhibitors are effective and safe for treating alopecia areata, but more research is needed.
research Platelet-rich plasma for androgenetic alopecia: intradermal injection or microneedle delivery?
The study compares the effectiveness of platelet-rich plasma (PRP) delivered via intradermal injection versus microneedle delivery for treating androgenetic alopecia. The research involved a sample size of 120 participants, divided into two groups, each receiving one of the treatment methods. Results indicated that both methods significantly improved hair density and thickness, but the microneedle delivery group showed slightly better outcomes in terms of patient satisfaction and hair regrowth. The study concludes that while both methods are effective, microneedle delivery may offer a marginal advantage in treating androgenetic alopecia.
research Formulation and Evaluation of Herbal Gummies
Herbal hair gummies with ingredients like fenugreek and biotin may help hair growth and are safe and stable.
research Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia Areata
Oil A formulation with Baricitinib shows promise for treating alopecia areata by promoting hair growth.
research Modulating Immune Responses in Alopecia: Therapeutic Insights and Potential Targets of Antisense Oligonucleotides
Targeting SIRT1 with antisense oligonucleotides could be a promising treatment for hair loss.
research Polydeoxyribonucleotide in Skincare and Cosmetics: Mechanisms, Therapeutic Applications, and Advancements Beyond Wound Healing and Anti-Aging
PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
research Hair Perming via Thiol-Michael Click Reaction: A Strategy to Avoid Oxidative Damage
A new hair perming method avoids damage and lasts longer than traditional methods.
research Understanding Eyebrow and Eyelash Involvement in Patients with Alopecia Areata and Responsiveness to Treatment with Baricitinib
Baricitinib effectively promotes regrowth of eyebrows and eyelashes in alopecia areata patients.
research Tissue Engineering and Nanoparticle-Based Approaches for Hair Follicle Regeneration
New methods using biomaterials, stem cells, and nanoparticles show promise for improving hair growth and treating hair loss.
research Anti-Vitiligo Mechanisms of Traditional Chinese Medicine Compound Baqia Danshen Liniment: Network Pharmacology, Molecular Docking, and Animal Model Insights
Compound Baqia Danshen Liniment may effectively treat vitiligo by improving skin and hair pigmentation and reducing inflammation.
research Analysis on the treatment compliance of patients with androgenetic alopecia and its influencing factors: based on the comparison between microneedle therapy and drug therapy
This study on 156 patients with androgenetic alopecia compared treatment adherence between microneedling therapy (70 patients) and drug therapy (86 patients). The microneedling group showed higher adherence, influenced by factors like age, education, income, treatment duration, and side effects. Patients over 30, with higher education and income, and shorter treatment durations adhered better. Improved treatment efficacy and reduced anxiety were linked to better adherence. In the drug group, side effects and treatment efficacy were key, with severe conditions and depression increasing non-adherence. Microneedling reduced side effects and improved mental health, suggesting advantages in adherence. Future research should focus on the long-term efficacy and safety of microneedling.
research Hemp Seed-Derived Exosomes Protect Against Dihydrotestosterone-Induced Hair Growth Inhibition
Hemp seed exosomes may help prevent hair loss caused by DHT.
research Integrating Ayurvedic Therapies With Minoxidil: A Randomized, Single-Blinded, Parallel-Controlled Trial Assessing the Efficacy and Safety of Traya's Customized Approach for Treating Male Androgenetic Alopecia
Combining Ayurvedic therapies with minoxidil is more effective for hair growth in men than using minoxidil alone.
research Blood pressure changes in patients after minoxidil microinfusion to treat female pattern alopecia: analysis of a randomized, single blinded, placebo controlled clinical trial
research Transcriptome Sequencing Reveals Expression Profiles of lncRNAs and mRNAs in Goat Skin Tissues with Different Wool Coat Types
Different wool coat types in goats are linked to specific gene expressions, which could improve cashmere quality.
research Early Exposure to Sexualized Content and Androgenetic Alopecia: Can Culture Shape Our Biology?
Early exposure to sexualized content and poor lifestyle choices may lead to early hair loss.
research Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway
Jiawei Erzhiwan helps hair growth in androgenetic alopecia by affecting specific cell pathways.
research The Efficacy of Topical Cetirizine Using Microneedling in Androgenetic Alopecia Male Patients
Topical cetirizine with microneedling effectively promotes hair growth in men with androgenetic alopecia.
research Formulation and Evaluation of Repurposed Ketoconazole-Loaded Transferosomal Gel for Enhanced Trichogenic Effects
The ketoconazole gel improved hair growth and is a promising treatment for hair loss.
research Angelica sinensis and Ligusticum sinense ‘Chuanxiong’ Leaf Essential Oils Promote Hair Growth without Acute Toxicity
The study found that essential oils from Angelica sinensis and Ligusticum sinense ‘Chuanxiong’ effectively promote hair growth in a DHT-induced alopecia model in mice, outperforming 3% minoxidil. The oils increased hair follicle numbers and dermal thickness, and enhanced hair growth-promoting factors in cell models, without causing acute toxicity. These findings suggest that these essential oils could be safe and effective for treating hair loss, with potential applications in aromatherapy and cosmetics. Future clinical evaluations are planned to further assess their efficacy.
research Corrigendum to ‘‘Medicinal and edible plant Allium macrostemon Bunge for the treatment of testosterone-induced androgenetic alopecia in mice’’ [J. Ethnopharmacol. 315 (2023) 116657]
research Identifying the Active Components and Mechanisms of Persicae Semen in Treating Androgenetic Alopecia: Insights from Network Pharmacology and Experimental Evaluations
The study investigates the active components and mechanisms of Persicae Semen (TR) in treating androgenetic alopecia (AGA) using advanced techniques like UPLC-Q-TOF-MS, network pharmacology, and molecular docking. Amygdalin (Am), identified as the main active compound in TR, was found to promote hair growth by influencing the Wnt/β-catenin and VEGF pathways. Additionally, Am can regulate androgen receptor (AR) and 5α-reductase, which are crucial in AGA development. These findings provide a foundation for the clinical use of TR in AGA treatment, offering a potential alternative to current treatments with significant side effects.
Research: Highly Cited
30 / 1000+ results
research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome
The 2003 consensus updated PCOS diagnosis criteria and highlighted increased risks of diabetes and heart disease for those affected.
research Derivation And Validation Of The Systemic Lupus International Collaborating Clinics Classification Criteria For Systemic Lupus Erythematosus
The new SLICC criteria for diagnosing lupus are more sensitive and accurate than the old criteria.
research Revised 2003 Consensus on Diagnostic Criteria and Long-Term Health Risks Related to Polycystic Ovary Syndrome (PCOS)
The 2003 consensus updated PCOS diagnosis criteria and linked PCOS to higher risks of diabetes and heart problems, recommending lifestyle changes to lower these risks.
research Standards of Care for the Health of Transsexual, Transgender, and Gender-Nonconforming People, Version 7
The guidelines recommend informed consent for gender-affirming treatments and stress the importance of personalized, culturally sensitive care for transgender individuals.
research Polycystic Ovary Syndrome: Clinical and Biochemical Features
PCOS is a common hormonal disorder causing irregular periods and increased hair growth, linked to insulin resistance and long-term health issues.
research Criteria for Defining Polycystic Ovary Syndrome as a Predominantly Hyperandrogenic Syndrome: An Androgen Excess Society Guideline
Polycystic Ovary Syndrome should be seen mainly as a condition of excess male hormones, with a focus on this in its definition.
research The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia
Combination therapy of doxazosin and finasteride safely and effectively reduces benign prostatic hyperplasia progression risk.
research The Androgen Excess and PCOS Society Criteria for the Polycystic Ovary Syndrome: The Complete Task Force Report
The report concludes that PCOS is mainly a condition of excess male hormones and its definition may change as new information is discovered.
research Vitamin D and Human Health: Lessons from Vitamin D Receptor Null Mice
Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
research Consensus on Women's Health Aspects of Polycystic Ovary Syndrome: The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Experts agree that PCOS affects women's health in complex ways, but more research is needed to understand and treat it effectively.
research Reduced Cardiotoxicity and Comparable Efficacy in a Phase III Trial of Pegylated Liposomal Doxorubicin HCl (CAELYX/Doxil) Versus Conventional Doxorubicin for First-Line Treatment of Metastatic Breast Cancer
Pegylated liposomal doxorubicin is as effective as conventional doxorubicin but causes fewer heart problems and side effects.
research The Rotterdam Study: Objectives And Design Update
The Rotterdam Study investigates diseases in older adults and has produced many research findings.
research A Comprehensive Review on Metabolic Syndrome
Managing metabolic syndrome needs both lifestyle changes and medical treatments.
research The Nuclear Vitamin D Receptor: Biological and Molecular Regulatory Properties Revealed
The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
research Diagnosis and Treatment of Polycystic Ovary Syndrome: An Endocrine Society Clinical Practice Guideline
The guideline suggests using specific criteria to diagnose PCOS, recommends various treatments for its symptoms, and advises screening for related health issues.
research More Than 50 Long-Term Effects of COVID-19: A Systematic Review and Meta-Analysis
COVID-19 leaves 80% of patients with long-term symptoms like fatigue and headaches.
research Wound Healing: A Cellular Perspective
The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
research The Biology of Hair Follicles
Hair follicle biology advancements may lead to better hair growth disorder treatments.
research The Side Effects of Platinum-Based Chemotherapy Drugs: A Review for Chemists
Platinum-based chemotherapy drugs can cause many severe side effects, often requiring dose reductions and additional medications to manage.
research MicroRNA Control of Signal Transduction
MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.
research The Nuts and Bolts of Low-Level Laser Therapy
Low-level Laser Therapy may help reduce inflammation, pain, and aid healing, but more research is needed to confirm its effectiveness and establish standard treatment guidelines.
research The Effect of Finasteride on the Risk of Acute Urinary Retention and the Need for Surgical Treatment Among Men with Benign Prostatic Hyperplasia
Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia
Finasteride effectively treats BPH but may increase sexual dysfunction risk.
research Epidermal Homeostasis: A Balancing Act of Stem Cells in the Skin
Skin stem cells are crucial for maintaining and repairing the skin and hair, using a complex mix of signals to do so.
research Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
Hair follicle stem cells can form both hair follicles and skin.
research Polycystic Ovary Syndrome: Etiology, Pathogenesis, and Diagnosis
The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
research Polycystic Ovary Syndrome: Comprehensive Overview and Diagnostic Criteria
PCOS is a complex condition with major health impacts, needing more research for better diagnosis and treatment.
research Epidemiology, Diagnosis, and Management of Polycystic Ovary Syndrome
PCOS is a common hormonal disorder in women that can be managed with lifestyle changes and various medications.
research Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
research Androgen Excess in Women: Experience with Over 1000 Consecutive Patients
Most women with excess male hormones have Polycystic Ovary Syndrome, and hormonal therapy can improve symptoms but may cause side effects.