Derivation And Validation Of The Systemic Lupus International Collaborating Clinics Classification Criteria For Systemic Lupus Erythematosus

    July 2012 in “ Arthritis & Rheumatism ”
    Michelle Petri, Ana‐Maria Orbai, Graciela S. Alarcón, Caroline Gordon, Joan T. Merrill, Paul R. Fortin, Ian N Bruce, David Isenberg, Daniel J. Wallace, Ola Nived, Gunnar Sturfelt, Rosalind Ramsey‐Goldman, Sang‐Cheol Bae, John G. Hanly, Jorge Sánchez‐Guerrero, Ann E. Clarke, Cynthia Aranow, Susan Manzi, Murray Urowitz, Dafna D. Gladman, Kenneth Kalunian, Melissa Costner, Victoria P. Werth, Asad Zoma, Sasha Bernatsky, Guillermo Ruíz-Irastorza, Munther A. Khamashta, Søren Jacobsen, Jill P. Buyon, Peter Lanyon, Mary Anne Dooley, Ronald van Vollenhoven, Ellen M. Ginzler, Thomas Stoll, Christine A. Peschken, Joseph L. Jorizzo, Jeffrey P. Callen, S. Sam Lim, Barri J. Fessler, Murat İnanç, Diane L. Kamen, Anisur Rahman, Kristján Steinsson, Andrew G. Franks, Lisa Sigler, Suhail Hameed, Hong Fang, Ngoc Minh Pham, Robin L. Brey, Philip M. Carlucci, Gerald McGwin, Laurence S. Magder
    TLDR The new SLICC criteria for diagnosing lupus are more sensitive and accurate than the old criteria.
    The SLICC group revised and validated the ACR classification criteria for systemic lupus erythematosus (SLE) using 702 expert-rated patient scenarios for derivation and 690 for validation. The new criteria identified 17 factors and showed improved sensitivity (94% vs. 86% in derivation; 97% vs. 83% in validation) and fewer misclassifications compared to the ACR criteria, though with slightly lower specificity in the validation set (84% vs. 96%). The SLICC criteria required patients to meet at least 4 criteria, including one clinical and one immunologic, or have biopsy-proven lupus nephritis with specific antibodies.
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