Derivation And Validation Of The Systemic Lupus International Collaborating Clinics Classification Criteria For Systemic Lupus Erythematosus

    May 2012 in “ Arthritis & Rheumatism ”
    Michelle Petri, Ana‐Maria Orbai, Graciela S. Alarcón, Caroline Gordon, Joan T. Merrill, Paul R. Fortin, Ian N Bruce, David Isenberg, Daniel J. Wallace, Ola Nived, Gunnar Sturfelt, Rosalind Ramsey‐Goldman, Sang‐Cheol Bae, John G. Hanly, Jorge Sánchez‐Guerrero, Ann E. Clarke, Cynthia Aranow, Susan Manzi, Murray Urowitz, Dafna D. Gladman, Kenneth Kalunian, Melissa Costner, Victoria P. Werth, Asad Zoma, Sasha Bernatsky, Guillermo Ruíz-Irastorza, Munther A. Khamashta, Søren Jacobsen, Jill P. Buyon, Peter Lanyon, Mary Anne Dooley, Ronald van Vollenhoven, Ellen M. Ginzler, Thomas Stoll, Christine A. Peschken, Joseph L. Jorizzo, Jeffrey P. Callen, S. Sam Lim, Barri J. Fessler, Murat İnanç, Diane L. Kamen, Anisur Rahman, Kristján Steinsson, Andrew G. Franks, Lisa Sigler, Suhail Hameed, Hong Fang, Ngoc Minh Pham, Robin L. Brey, Philip M. Carlucci, Gerald McGwin, Laurence S. Magder
    Studysummary This study found that the new SLICC classification criteria for systemic lupus erythematosus were more sensitive and resulted in fewer misclassifications than the current ACR criteria, although they had lower specificity.
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    The Systemic Lupus International Collaborating Clinics (SLICC) developed and validated new classification criteria for systemic lupus erythematosus (SLE) to improve diagnostic accuracy. The study involved 702 patients for derivation and 690 for validation, showing the SLICC criteria had higher sensitivity (97% vs. 83%) but lower specificity (84% vs. 96%) compared to the American College of Rheumatology (ACR) criteria. The SLICC criteria required at least one clinical and one immunologic criterion or lupus nephritis with specific antibodies, resulting in fewer misclassifications and better alignment with current SLE knowledge.
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