Adjunctive Dupilumab Therapy in a Partial Responder to Baricitinib for Alopecia Areata

July 2025 in “ SKIN The Journal of Cutaneous Medicine ”

Eingun James Song

alopecia areata ophiasis pattern baricitinib oral minoxidil dupilumab JAK inhibitors immunomodulatory agents Alopecia

TLDR Adding dupilumab led to almost complete hair regrowth in a patient with alopecia areata who only partially responded to baricitinib.

This article discusses a case of severe alopecia areata with a predominant ophiasis pattern, where the patient partially responded to baricitinib 4 mg daily and oral minoxidil over 15 months. However, after the addition of dupilumab, the patient experienced near complete hair regrowth within just 2 months. This case highlights the potential of using combination immunomodulatory agents, such as dupilumab, to enhance treatment responses in refractory cases of alopecia areata, especially when initial treatments with JAK inhibitors like baricitinib do not achieve desired outcomes.

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Research cited in this study

4 / 4 results

Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials

research Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials

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Hair regrowth from severe alopecia areata treatment with baricitinib can vary, with faster results in those with shorter hair loss duration.

research Janus Kinase Inhibitors For Alopecia Areata

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JAK inhibitors effectively improve hair regrowth in alopecia areata with an acceptable safety profile.

research Combination Tofacitinib and Oral Minoxidil Treatment for Severe Alopecia Areata

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Tofacitinib and oral minoxidil together effectively regrow hair in severe alopecia areata patients.

research Drug-Induced Alopecia After Dupilumab Therapy

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Dupilumab may cause significant hair loss, which can reverse after stopping the drug.

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Adjunctive Dupilumab Therapy in a Partial Responder to Baricitinib for Alopecia Areata

Research cited in this study

research Expecting Scalp Hair Regrowth During Severe Alopecia Areata Treatment with Baricitinib: Insights from Patient Trajectories in Phase III Trials

research Janus Kinase Inhibitors For Alopecia Areata

research Combination Tofacitinib and Oral Minoxidil Treatment for Severe Alopecia Areata

research Drug-Induced Alopecia After Dupilumab Therapy

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