Drug-induced alopecia after dupilumab therapy
January 2019
in “JAAD case reports”
TLDR Dupilumab may cause significant hair loss, which can reverse after stopping the drug.
This case report described a 27-year-old Hispanic man who developed drug-induced alopecia after 18 weeks of dupilumab therapy for atopic dermatitis. Despite initial improvements in his skin condition, he experienced significant hair loss, which did not improve with topical treatments. A punch biopsy revealed alopecia areata-like hair miniaturization and severe sebaceous gland atrophy. After discontinuing dupilumab and receiving intralesional steroid injections, the patient's hair loss reversed within 8 weeks. The report suggested a strong correlation between dupilumab and alopecia, though causation could not be definitively established. Further research was recommended to understand the underlying mechanisms and to guide treatment.
View this study on jaadcasereports.org →
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