Alopecia Areata Associated With Dupilumab: A Case Report And Literature Review

    July 2025
    Vignesh Ramachandran
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    TLDR Dupilumab may cause hair loss, so patients should be monitored.
    This case report and literature review discuss a rare adverse effect of dupilumab, a treatment for atopic dermatitis, which may trigger alopecia areata (AA), an autoimmune condition causing hair loss. A 47-year-old female developed AA after six months on dupilumab, but experienced complete hair regrowth within 12 weeks after stopping the drug and starting a new treatment regimen. The case suggests dupilumab may disrupt follicular homeostasis or enhance Th1/Th17 pathways, leading to AA. Clinicians should monitor for AA in patients on dupilumab, especially those with atopic or autoimmune predispositions. The report calls for further research to understand the mechanisms and risk factors, and emphasizes the importance of routine scalp examinations and patient education for early detection of hair loss.
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      community Alopecia Areata Question

      in Treatment  2 upvotes 4 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 1 year ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

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