Dupilumab Therapy for Alopecia Areata in a 4-Year-Old Patient Resistant to Baricitinib

    October 2023 in “ Frontiers in Medicine ”
    Lu Cai, Yu‐Ching Wei, Zhao Min, Jia Zhuo, Xiao Hua Tao, Mao Lin
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    TLDR Dupilumab helped a 4-year-old grow hair back after another treatment failed.
    The document discusses a case study of a 4-year-old patient with alopecia universalis, a severe form of alopecia areata, who didn't respond to the JAK inhibitor baricitinib but showed positive results with dupilumab therapy. After 10 months of treatment, the patient experienced hair regrowth on the scalp, eyebrows, and eyelashes. Dupilumab, a human monoclonal IgG4 antibody, regulates Th2 inflammatory responses and has proven effective in patients with alopecia areata, especially those with high levels of IgE. The study suggests that dupilumab could be a promising treatment for severe alopecia areata patients resistant to JAK inhibitors, particularly in pediatric patients. This is the first report of successful treatment with dupilumab in a patient under 6 years old who was resistant to JAK inhibitors.
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      community Alopecia Areata Question

      in Treatment  2 upvotes 4 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 2 years ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community Hairloss all over body and head

      in Treatment  2 upvotes 1 month ago
      A 25-year-old experiencing hair thinning all over the body and head, despite using minoxidil and having low vitamin D levels, is advised to seek a second opinion from a dermatologist specializing in hair loss. The likely diagnosis is diffuse alopecia areata, which may require treatment with a JAK inhibitor.

      community Aminexil, Nanoxidil, Stemoxydine and Kopexil. Anyone use them?

      in Question  1 upvotes 8 years ago
      Aminexil, nanoxidil, stemoxydine, and kopexil are discussed as alternatives to minoxidil for hair growth, with concerns about dependence. Minoxidil is noted for its effectiveness in transitioning hair growth phases, but dependence is mainly linked to androgenic alopecia.

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