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GlossaryImmunoglobulin E (IgE)

antibody involved in allergic reactions and parasite defense

Immunoglobulin E (IgE) is a type of antibody produced by the immune system. It plays a crucial role in allergic reactions by binding to allergens and triggering the release of histamine and other chemicals from mast cells and basophils, leading to symptoms like itching, swelling, and redness. Elevated levels of IgE are often associated with conditions such as asthma, hay fever, and eczema.

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research Netherton's Syndrome: A Syndrome of Elevated IgE and Characteristic Skin and Hair Findings

124 citations, January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology”

Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.

Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

research Diffuse Alopecia Areata Is Associated With Intense Inflammatory Infiltration and CD8+ T Cells in Hair Loss Regions and an Increase in Serum IgE Level

24 citations, January 2012 in “Indian Journal of Dermatology, Venereology and Leprology”

Diffuse alopecia areata involves more inflammation and higher allergy-related antibodies than patchy types.

research Expanding The Phenotype Of Hyper-IgE Syndrome: Heterozygous Variant In IL6ST With Elevated Serum IgE And Isolated Abscesses

January 2024 in “Genetics in Medicine Open”

A new IL6ST gene variant may cause a unique form of hyper-IgE syndrome with skin abscesses and high IgE levels.

Efficacy of Dupilumab in Treating Atopic Dermatitis With Recurrent Eczema Herpeticum in a Patient With DOCK8-Deficiency Hyper-IgE Syndrome: A Case Report

research Efficacy of Dupilumab in Treating Atopic Dermatitis With Recurrent Eczema Herpeticum in a Patient With DOCK8-Deficiency Hyper-IgE Syndrome: A Case Report

August 2023 in “Cureus”

Dupilumab helped improve skin and prevent new lesions in a child with a rare immune disorder and severe eczema.

research Lanceolate Hair-J (LahJ): A Mouse Model for Human Hair Disorders

37 citations, June 2000 in “Experimental dermatology”

The Lanceolate hair-J mutation in mice mimics human hair disorders like Netherton's syndrome.

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community Expectations control for SCUBE3

in Research/Science 21 upvotes 9 months ago

SCUBE3, a protein linked to hair growth in moles, was discovered over 25 years ago and is being developed by Amplifica for potential hair loss treatment. Concerns exist about SCUBE3's association with cancer, as it is a protein that promotes cell growth, which could potentially trigger cancer development if used for hair growth therapy.

community Prediction: Scube3 is never coming out

in Research/Science 6 upvotes 9 months ago

Scube3, a potential hair loss treatment, is unlikely to be released because it was given to a startup company, Amplifica, which may go bankrupt and fail to bring the treatment to market. Amplifica is prioritizing other treatments over Scube3, which could lead to financial loss and the end of Scube3's development.

community Amplifica and AMP-303 clinical phase 1

in Research/Science 9 upvotes 11 months ago

Amplifica is testing a compound called AMP-303 for hair loss, but it's not Scube3 or osteopontin. The timing for the results from the clinical trial is unknown.

community No idea what's causing my hair thinning

in Chat 2 upvotes 2 months ago

The user is experiencing diffuse hair thinning despite using finasteride and oral minoxidil, with no hairline recession or bald spots. Suggestions include checking for telogen effluvium, considering a JAK inhibitor for potential autoimmune issues, and conducting further tests to rule out other causes.

community SCUBE3 IS A GO! Clinical trials planned for later this year

in Research/Science 99 upvotes 1 year ago

SCUBE3 clinical trials for hair loss treatment to start this year. Treatment may involve regular, painless scalp injections to maintain hair growth.

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