Unveiling the Effect of Age and IgE Level on Alopecia Areata: Insights from Comparative RNAseq Analysis

    January 2025 in “ Clinical Cosmetic and Investigational Dermatology ”
    Huiting Liu, Sai Yang, Hua Xian, Yinghui Liu, Yan Zhang, Yangxia Chen, Yingping Xu, Jun Liu, Bin Yang, Yigui Luo
    TLDR Pediatric alopecia areata is more immune-active than adult cases, suggesting age-specific treatments and potential use of JAK inhibitors.
    The study examines the effects of age and IgE levels on alopecia areata (AA) by analyzing gene expression in scalp samples from 28 patients, including 6 pediatric and 22 adult patients. It finds that pediatric AA shows more active immune-inflammatory pathways than adult AA, with distinct gene expression profiles. Elevated IgE levels were found in 39.2% of patients, indicating a potential link to AA severity. The study emphasizes the need for age-specific treatments, as pediatric AA has unique molecular characteristics. It also highlights the role of CD8+ T cells in AA pathogenesis and notes increased immune cell infiltration in pediatric cases. The findings suggest that JAK inhibitors could be a promising treatment and stress the importance of personalized strategies based on age and allergy status.
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