Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata

    July 2020 in “ Experimental dermatology ”
    Marta Bertolini, Kevin J. McElwee, Amos Gilhar … Ralf Paus
    Studysummary This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 101

    1. Joint Study of the Associations of HLA-B and the Transmembrane Short Tandem Repeat Polymorphism of MICA Protein with Alopecia Areata Shows Independent Associations of Both with the Disease Clinical and Experimental Dermatology · 2020
    2. A Hair-Raising History of Alopecia Areata Experimental Dermatology · 2020
    3. Association of Autoimmune Regulator Gene Rs2075876 Variant, but Not Gene Expression, with Alopecia Areata in Males: A Case-Control Study Immunological investigations · 2019
    4. Frontiers in Alopecia Areata Pathobiology Research ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    5. 2-Deoxy D-Glucose Treatment Does Not Elicit a Hair Growth Response in Alopecia Areata Experimental Dermatology · 2019
    6. Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease PloS one · 2019
    7. Can We Teach Old Drugs New Tricks? Repurposing Neuropharmacological Drugs for Inflammatory Skin Diseases Experimental Dermatology · 2019
    8. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    9. Possible Role of ILC1 in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    10. Regulatory T-Cells in Alopecia Areata Journal of cutaneous pathology · 2019
    11. The Role of the Microbiome in Scalp Hair Follicle Biology and Disease Experimental Dermatology · 2019
    12. Hair Growth Control by Innate Immunocytes: Perifollicular Macrophages Revisited Experimental Dermatology · 2019
    13. JAK Inhibitors and Alopecia Areata Lancet · 2019
    14. Effects of Mesenchymal Stem Cell Therapy on Alopecia Areata in Cellular and Hair Follicle Organ Culture Models Experimental Dermatology · 2018
    15. Response to Ustekinumab in Three Pediatric Patients with Alopecia Areata Pediatric dermatology · 2018
    16. Sequential Cyclic Changes of Hair Roots Revealed by Dermoscopy Demonstrate a Progressive Mechanism of Diffuse Alopecia Areata Over Time Experimental Dermatology · 2018
    17. High-Throughput T Cell Receptor Sequencing Identifies Clonally Expanded CD8+ T Cell Populations in Alopecia Areata JCI insight · 2018
    18. Immunoregulatory Effects of Myeloid-Derived Suppressor Cell Exosomes in Mouse Model of Autoimmune Alopecia Areata Frontiers in immunology · 2018
    19. Alopecia Areata: A Review of Disease Pathogenesis British journal of dermatology/British journal of dermatology, Supplement · 2018
    20. Cellular Therapy with Human Autologous Adipose-Derived Adult Cells of Stromal Vascular Fraction for Alopecia Areata Stem Cell Research & Therapy · 2018
    21. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    22. Lichen Planopilaris and Frontal Fibrosing Alopecia as Model Epithelial Stem Cell Diseases Trends in Molecular Medicine · 2018
    23. Autophagy Is Essential for Maintaining the Growth of a Human Mini-Organ: Evidence from Scalp Hair Follicle Organ Culture PLOS Biology · 2018
    24. Regulatory T Cells in Autoimmune Skin Diseases Experimental Dermatology · 2018
    25. A Technique for More Precise Distinction Between Catagen and Telogen Human Hair Follicles Ex Vivo Journal of The American Academy of Dermatology · 2018
    26. Cicatricial Alopecia Research Foundation Meeting, May 2016: Progress Towards the Diagnosis, Treatment, and Cure of Primary Cicatricial Alopecias Experimental Dermatology · 2018
    27. Large-Scale Epitope Identification Screen and Its Potential Application to the Study of Alopecia Areata ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    28. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    29. An Overview of the Biology of Platelet-Rich Plasma and Microneedling as Potential Treatments for Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2017
    30. Getting to the Root of Scales, Feathers, and Hair: As Deep as Odontodes? Experimental Dermatology · 2017
    31. CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia Experimental dermatology · 2017
    32. Th1/Th2 Peripheral Blood Balance and CD200 Expression in Patients with Active Severe Alopecia Areata Experimental and Therapeutic Medicine · 2017
    33. Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors British journal of dermatology/British journal of dermatology, Supplement · 2016
    34. T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus Experimental dermatology · 2016
    35. Successful Hair Regrowth in an Acute Diffuse Form of Alopecia Areata During Oral Tacrolimus Treatment in a Patient With Rheumatoid Arthritis Journal of the European Academy of Dermatology and Venereology · 2016
    36. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    37. Genomewide Analysis of Copy Number Variants in Alopecia Areata in a Central European Cohort Reveals Association with MCHR2 Experimental Dermatology · 2016
    38. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    39. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
    40. Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment Experimental dermatology · 2015
    41. Extensive Alopecia Areata Is Reversed by IL-12/IL-23p40 Cytokine Antagonism The Journal of Allergy and Clinical Immunology · 2015
    42. Hair Follicle-Derived IL-7 and IL-15 Mediate Skin-Resident Memory T Cell Homeostasis and Lymphoma Nature medicine · 2015
    43. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015
    44. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    45. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    46. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    47. Hair Regrowth in Alopecia Areata Patients Following Stem Cell Educator Therapy BMC medicine · 2015
    48. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    49. The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
    50. Alopecia Universalis Successfully Treated With Adalimumab JAMA dermatology · 2014
    51. The Autoimmune Basis of Alopecia Areata: A Comprehensive Review Autoimmunity reviews · 2014
    52. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    53. Neuroendocrinology of the Hair Follicle: Principles and Clinical Perspectives Trends in Molecular Medicine · 2014
    54. Beneficial Effects of Astragaloside IV for Hair Loss via Inhibition of Fas/FasL-Mediated Apoptotic Signaling PloS one · 2014
    55. Vitiligo and Alopecia Areata: Apples and Oranges? Experimental Dermatology · 2013
    56. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    57. Early Stage Alopecia Areata Is Associated With Inflammation in the Upper Dermis and Damage to the Hair Follicle Infundibulum Australasian Journal of Dermatology · 2013
    58. Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche The Journal of Pathology · 2013
    59. Blocking Potassium Channels (Kv1.3): A New Treatment Option for Alopecia Areata? Journal of Investigative Dermatology · 2013
    60. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    61. Autoimmune Disease Induction in a Healthy Human Organ: A Humanized Mouse Model of Alopecia Areata Journal of Investigative Dermatology · 2012
    62. Endogenous Retinoids in the Pathogenesis of Alopecia Areata ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2012
    63. Alopecia Areata as a Model for T Cell-Dependent Autoimmune Diseases Experimental Dermatology · 2012
    64. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    65. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    66. Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege? Investigative Ophthalmology & Visual Science · 2011
    67. The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011
    68. Involvement of the Bulge Region with Decreased Expression of Hair Follicle Stem Cell Markers in Senile Female Cases of Alopecia Areata JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2010
    69. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    70. Alopecia Areata as Another Immune-Mediated Disease Developed in Patients Treated with Tumor Necrosis Factor-Alpha Blocker Agents Journal of the European Academy of Dermatology and Venereology · 2010
    71. Diphencyprone and Topical Tacrolimus as Two Topical Immunotherapeutic Modalities: Are They Effective in the Treatment of Alopecia Areata Among Egyptian Patients? A Study Using CD4, CD8, and MHC II as Markers Journal of dermatological treatment · 2010
    72. Natural Killer Cells in Atopic and Autoimmune Skin Diseases Journal of Allergy and Clinical Immunology · 2010
    73. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    74. The C3H/HeJ Mouse and DEBR Rat Models for Alopecia Areata: Review of Preclinical Drug Screening Approaches and Results Experimental dermatology · 2008
    75. Hair Physiology and Its Disorders Drug Discovery Today: Disease Mechanisms · 2008
    76. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008
    77. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    78. Complex Hair Cycle Domain Patterns and Regenerative Hair Waves in Living Rodents Journal of Investigative Dermatology · 2007
    79. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    80. Lymphocytes, Neuropeptides, And Genes Involved In Alopecia Areata Journal of Clinical Investigation · 2007
    81. Anti-CD44-Mediated Blockade of Leukocyte Migration in Skin-Associated Immune Diseases Journal of Leukocyte Biology · 2007
    82. Neuroimmunology of Stress: Skin Takes Center Stage Journal of Investigative Dermatology · 2006
    83. Keratin 17 Modulates Hair Follicle Cycling in a TNFα-Dependent Fashion Genes & Development · 2006
    84. A Chronic Contact Eczema Impedes Migration of Antigen-Presenting Cells in Alopecia Areata Journal of Investigative Dermatology · 2006
    85. Neuroimmunoendocrine Circuitry of the Brain-Skin Connection Trends in Immunology · 2005
    86. Immunology of the Human Nail Apparatus: The Nail Matrix Is a Site of Relative Immune Privilege Journal of Investigative Dermatology · 2005
    87. Human Hair Follicles Display a Functional Equivalent of the Hypothalamic-Pituitary-Adrenal (HPA) Axis and Synthesize Cortisol The FASEB Journal · 2005
    88. Mast Cell Deficient and Neurokinin-1 Receptor Knockout Mice Are Protected from Stress-Induced Hair Growth Inhibition Journal of Molecular Medicine · 2005
    89. Apoptosis Resistance in Peripheral Blood Lymphocytes of Alopecia Areata Patients Journal of Autoimmunity · 2004
    90. Alopecia Areata in C3H/HeJ Mice Involves Leukocyte-Mediated Root Sheath Disruption in Advance of Overt Hair Loss Veterinary pathology · 2003
    91. Role of the Autoimmune Regulator (AIRE) Gene in Alopecia Areata: Strong Association of a Potentially Functional AIRE Polymorphism With Alopecia Universalis Tissue Antigens · 2002
    92. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002
    93. Alopecia Areata: Animal Models Clinical and Experimental Dermatology · 2002
    94. Transient CD44 Variant Isoform Expression and Reduction in CD4+/CD25+ Regulatory T Cells in C3H/HeJ Mice with Alopecia Areata Journal of Investigative Dermatology · 2002
    95. Developmental Timing of Hair Follicle and Dorsal Skin Innervation in Mice Journal of comparative neurology · 2002
    96. Current and Potential Agents for the Treatment of Alopecia Areata Current pharmaceutical design · 2001
    97. The Anagen Hair Cycle Induces Systemic Immunosuppression of Contact Hypersensitivity in Mice Cellular Immunology · 1998
    98. Neural Mechanisms of Hair Growth Control Journal of Investigative Dermatology Symposium Proceedings · 1997
    99. Hair Cycle-Dependent Changes in Skin Immune Functions: Anagen-Associated Depression of Sensitization for Contact Hypersensitivity in Mice Journal of Investigative Dermatology · 1996
    100. Immunohistochemical and Electron Microscopic Characterization of the Cellular Infiltrate in Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 1984
    101. Distribution of Major Histocompatibility Antigens in Normal Skin British Journal of Dermatology · 1983

    Related research 8

    1. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    2. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    4. Current Status of Treatments for Alopecia Areata 2014
    5. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    6. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011
    7. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009
    8. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005