Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management

    December 2017 in “ ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings ”
    Ralf Paus, Silvia Bulfone–Paus∥, Marta Bertolini
    Studysummary This review discusses the role of immune privilege collapse in the pathogenesis of alopecia areata, emphasizing the potential for therapeutic manipulation of hair bulb immune privilege to offer new treatment options, and reports no new results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 41

    1. CD80CD86 Deficiency Disrupts Regulatory CD4+FoxP3+ T Cell Homeostasis and Induces Autoimmune-Like Alopecia Experimental dermatology · 2017
    2. Review of Treatment for Alopecia Totalis and Alopecia Universalis International Journal of Dermatology · 2017
    3. SOCS3 Treatment Prevents the Development of Alopecia Areata by Inhibiting CD8+ T Cell-Mediated Autoimmune Destruction Oncotarget · 2017
    4. Commensal Microbes and Hair Follicle Morphogenesis Coordinately Drive Treg Migration into Neonatal Skin Cell host & microbe · 2017
    5. Immune-Related Alopecia (Areata and Universalis) in Cancer Patients Receiving Immune Checkpoint Inhibitors British journal of dermatology/British journal of dermatology, Supplement · 2016
    6. Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients Journal of The American Academy of Dermatology · 2016
    7. T-Cell Induced-Self MHC Class I/Peptide Complexes May Enable De Novo Tolerance Induction to Neo-Antigens Occurring Outside of the Thymus Experimental dermatology · 2016
    8. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    9. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    10. Vδ1+ T-Cells Are Stress-Sentinels in Human Skin and Are Implicated in Alopecia Areata Pathogenesis Journal of Investigative Dermatology · 2016
    11. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    12. Genomewide Analysis of Copy Number Variants in Alopecia Areata in a Central European Cohort Reveals Association with MCHR2 Experimental Dermatology · 2016
    13. ULBP3: A Marker for Alopecia Areata Incognita Archives of Dermatological Research · 2016
    14. Vasoactive Intestinal Peptide, Whose Receptor-Mediated Signaling May Be Defective in Alopecia Areata, Provides Protection from Hair Follicle Immune Privilege Collapse British journal of dermatology/British journal of dermatology, Supplement · 2016
    15. Alopecia Areata: Animal Models Illuminate Autoimmune Pathogenesis and Novel Immunotherapeutic Strategies Autoimmunity reviews · 2016
    16. Laser Capture Microdissection Reveals Transcriptional Abnormalities In Alopecia Areata Before, During, And After Active Hair Loss Journal of Investigative Dermatology · 2015
    17. Retrospective Review of Diphencyprone in the Treatment of Alopecia Areata Clinical and Experimental Dermatology · 2015
    18. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    19. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    20. Imbalance of T-Helper 17 and Regulatory T Cells in Patients with Alopecia Areata The Journal of Dermatology · 2015
    21. Organ Specificity in Autoimmune Diseases: Thyroid and Islet Autoimmunity in Alopecia Areata The Journal of Clinical Endocrinology & Metabolism · 2015
    22. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    23. Macrophages Contribute to the Cyclic Activation of Adult Hair Follicle Stem Cells PLoS Biology · 2014
    24. The PDE4 Inhibitor, Apremilast, Suppresses Experimentally Induced Alopecia Areata in Human Skin In Vivo Journal of Dermatological Science · 2014
    25. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    26. Hair Follicle Mesenchyme-Associated PD-L1 Regulates T-Cell Activation Induced Apoptosis: A Potential Mechanism of Immune Privilege Journal of Investigative Dermatology · 2013
    27. Birth, Life, and Death of the MAGE3 Hypothesis of Alopecia Areata Pathobiology Journal of Dermatological Science · 2013
    28. Blocking Potassium Channels (Kv1.3): A New Treatment Option for Alopecia Areata? Journal of Investigative Dermatology · 2013
    29. Somatostatin Expression in Human Hair Follicles and Its Potential Role in Immune Privilege ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2013
    30. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    31. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    32. Histopathologic Features of Alopecia Areata Incognito: A Review of 46 Cases Journal of Cutaneous Pathology · 2012
    33. Calcitonin Gene-Related Peptide (CGRP) May Award Relative Protection from Interferon-γ-Induced Collapse of Human Hair Follicle Immune Privilege Experimental Dermatology · 2011
    34. Can the Hair Follicle Become a Model for Studying Selected Aspects of Human Ocular Immune Privilege? Investigative Ophthalmology & Visual Science · 2011
    35. The Autoimmune Regulator (AIRE), Defective in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy Patients, Is Expressed in Human Epidermal and Follicular Keratinocytes and Associates With the Intermediate Filament Protein Cytokeratin 17 ˜The œAmerican journal of pathology · 2011
    36. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    37. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    38. Probing the Effects of Stress Mediators on the Human Hair Follicle American Journal of Pathology · 2007
    39. Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone Archives of dermatological research · 2007
    40. Hair Cycle-Dependent Changes in Skin Immune Functions: Anagen-Associated Depression of Sensitization for Contact Hypersensitivity in Mice Journal of Investigative Dermatology · 1996
    41. Distribution of Major Histocompatibility Antigens in Normal Skin British Journal of Dermatology · 1983

    Related research 8

    1. Oxidative Stress and Alopecia Areata Frontiers in medicine · 2023
    2. Understanding Immune Privilege in an Inducible Mouse Model of Primary Cicatricial Alopecia ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2023
    3. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    4. Current Status of Treatments for Alopecia Areata 2014
    5. The Role of Hair Follicle Immune Privilege Collapse in Alopecia Areata: Status and Perspectives Journal of Investigative Dermatology Symposium Proceedings · 2013
    6. The Immunopathobiology of Lichen Planopilaris [Thesis]. Manchester, UK: The University of Manchester; 2011. · 2011
    7. Does Collapse of Immune Privilege in the Hair-Follicle Bulge Play a Role in the Pathogenesis of Primary Cicatricial Alopecia? Clinical and Experimental Dermatology · 2009
    8. Alopecia Areata: A Tissue-Specific Autoimmune Disease of the Hair Follicle Autoimmunity Reviews · 2005