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research Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

136 citations , April 2013 in “Clinical Cancer Research”

The study found that IPI-926 was well tolerated up to 160 mg once daily for 28-day cycles and showed activity as a single-agent treatment in Hedgehog pathway inhibitor-naïve patients with basal cell carcinoma.

research Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral‐nerve injury: An advantageous alternative to ES and iPS cells

121 citations , June 2009 in “Journal of Cellular Biochemistry”

In this study, human hair follicle pluripotent stem cells transplanted into severed mouse sciatic nerves differentiated into Schwann cells and supported nerve regeneration, offering a promising alternative to embryonic or iPS cells for regenerative medicine.

research Bioengineering a 3D integumentary organ system from iPS cells using an in vivo transplantation model

77 citations , April 2016 in “Science Advances”

Researchers created a fully functional, bioengineered skin system with hair from stem cells that successfully integrated when transplanted into mice.

research External light activates hair follicle stem cells through eyes via an ipRGC–SCN–sympathetic neural pathway

61 citations , June 2018 in “Proceedings of the National Academy of Sciences of the United States of America”

This study found that light stimulation of intrinsically photosensitive retinal ganglion cells in the eyes can activate hair follicle stem cells through a neural circuit involving the sympathetic nervous system.

research Pneumatic skin flattening (PSF): A novel technology for marked pain reduction in hair removal with high energy density lasers and IPLs

39 citations , January 2006 in “Journal of Cosmetic and Laser Therapy”

This study found that pneumatic skin flattening (PSF) significantly reduces pain and post-treatment erythema during high-energy IPL and laser hair removal while enhancing treatment efficacy.

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Community Join

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community Using facial landmarks and IPD normalization for longitudinal hairline tracking

4 upvotes 2 weeks ago

A user is developing an app called Follicle to track hairline changes using facial landmarks and inter-pupillary distance for standardization. The app aims to provide a more consistent way for consumers to monitor hairline changes over time.

community Following the recent IPO and the positive Phase 3 clinical data for VDPHL01 (extended-release oral minoxidil), what is the projected timeline for the FDA submission and the subsequent commercial availability on the market?

in Chat 4 upvotes 5 months ago

Veradermics' extended-release oral minoxidil is expected to be commercially available in 2027-2028, while another company, Minx, may release a similar product sooner. VDPHL01 is considered more clinically validated compared to Minx.

community Anyone looking at lab-grown hair studies using iPSC?

in Research/Science 2 upvotes 5 months ago

Lab-grown hair using iPSCs is being explored, but practical applications are limited. Finasteride is suggested as the only current effective treatment.

community Can I use wound cleanser to make topical finasteride, it contains 70% IPA and rest Purified Water?

4 upvotes 2 years ago

The user wants to make a topical finasteride solution using wound cleanser with 70% IPA and add 40% propylene glycol due to headaches from minoxidil. They seek advice on using the wound cleanser and recommendations for pharmaceutical/cosmetic grade IPA in India.

community The greatest head of hair of all time has left us today. R.I.P., David Lynch.

2039 upvotes 1 year ago

David Lynch is remembered for his impressive hairline, sparking discussions about genetics and hair loss. Users humorously speculate on hair loss treatments and genetics, mentioning names like Minoxidil and finasteride.

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