Changes in Distribution Pattern of CD8 Lymphocytes in the Scalp in Alopecia Areata During Treatment With Diphenylcyclopropenone

The 2007 study examined the effect of diphencyprone (DCP) treatment on CD8 lymphocyte distribution in the scalp of 20 patients with alopecia areata (AA). It found a significant increase in CD8 lymphocytes in the epithelium and around hair follicles in patients who had a good response to DCP, with no change observed around blood vessels. The increase in CD8 lymphocytes was associated with hair regrowth, suggesting that DCP may help restore normal immune function against hair antigens. Additionally, a local inflammatory reaction to DCP was common in responders, indicating a potential immunomodulatory mechanism. The study reported that 70% of patients achieved cosmetically acceptable hair regrowth, with 30% reaching complete regrowth and 40% having incomplete but satisfactory regrowth.