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GlossaryDiphenylcyclopropenone

topical immunotherapy agent used to treat alopecia areata

Diphenylcyclopropenone (DPCP) is a topical immunotherapy agent used primarily to treat alopecia areata, a condition that causes hair loss. It works by inducing a mild allergic reaction on the scalp, which is thought to distract the immune system from attacking hair follicles, thereby promoting hair regrowth.

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Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

research Efficacy and Safety of Diphenylcyclopropenone Alone or in Combination with Anthralin in the Treatment of Chronic Extensive Alopecia Areata: A Retrospective Case Series

44 citations, February 2015 in “Journal of the American Academy of Dermatology”

Combining diphenylcyclopropenone with anthralin is more effective for hair regrowth in alopecia areata than using diphenylcyclopropenone alone, but may cause more side effects.

research Clinical Efficacy of Diphenylcyclopropenone in Alopecia Areata: Retrospective Data Analysis of 50 Patients

41 citations, November 2015 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Diphenylcyclopropenone (DPCP) can help regrow hair in many alopecia areata patients but may cause side effects and relapses.

research Topical Immunotherapy of Severe Alopecia Areata with Diphenylcyclopropenone: Experience in an Iranian Population

36 citations, May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

research Systematic Review and Quality Analysis of Studies on the Efficacy of Topical Diphenylcyclopropenone Treatment for Alopecia Areata

21 citations, June 2017 in “Journal of The American Academy of Dermatology”

Topical DPCP is somewhat effective for hair loss in alopecia areata, but more research is needed.

research Efficacy and Safety of Anthralin in Combination with Diphenylcyclopropenone in the Treatment of Alopecia Areata: A Retrospective Case Series

20 citations, June 2019 in “Archives of dermatological research”

Combining DPCP and anthralin helps regrow hair in some alopecia areata patients.

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