DUPA, Non Responders and Connective Tissue Disorders 6/12/2025
A 27-year-old male with diffuse hair loss, including the donor area, did not respond to finasteride, dutasteride, or minoxidil. He suspects his hair loss may be linked to a mild connective tissue disorder, possibly affecting the structural support of hair follicles, rather than being purely hormonal.
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6 / 6 resultscommunity DUPA/Retrograde might not be DHT based...GET A BIOPSY QUICK or permanent Hair Loss!
DUPA and retrograde alopecia may not be solely DHT-based, and a biopsy is crucial for accurate diagnosis and treatment. Treatments mentioned include dutasteride, oral minoxidil, pioglitazone, clobetasol, calcipotriol, ketoconazole, and doxycycline, depending on the specific condition.
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Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.
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A user experienced significant hair regrowth after 24 months using 1mg daily Dutasteride and 2.5-5mg oral Minoxidil for diffuse unpatterned alopecia. The discussion covers treatment effectiveness, side effects, and comparisons with Finasteride.
community 1.5 Year Update: 18 Months of 1mg Dutasteride Daily and 2.5-5mg Oral Minoxidil Daily on Diffuse Unpatterned Alopecia
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community Why is diffuse thinning so hard to recover, 3 plus years on meds!
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A 23-year-old male is experiencing aggressive hair loss despite using 1mg finasteride and 4.5mg minoxidil, with limited progress and side effects like fluid retention. Suggestions include trying dutasteride, microneedling with topical minoxidil, and considering hair systems or a transplant in the future.
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