Androgenetic, Diffuse, and Senescent Alopecia in Men: Practical Evaluation and Management

    January 2015 in “ Current problems in dermatology ”
    Fernanda Torres
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    TLDR The conclusion is that treatments like finasteride and minoxidil can prevent baldness progression and improve hair density, but more research is needed on other therapies.
    The document from 2015 discusses male baldness, including androgenetic alopecia, diffuse baldness, and senescent alopecia, focusing on evaluation methods and management strategies. It highlights the role of dihydrotestosterone (DHT) in hair follicle miniaturization and the impact of genetics and environmental factors on hair loss. The document notes the association of male baldness with increased risks of coronary heart disease and prostate cancer. It details FDA-approved treatments like oral finasteride and topical minoxidil, which are effective in preventing baldness progression and improving hair density. Other treatments such as dutasteride, vitamins, minerals, herbal compounds, laser and light therapy, and hair transplant surgery are also discussed, though some lack strong evidence. The document calls for more research on these therapies, acknowledging that even senescent alopecia in the elderly may respond to treatments like finasteride.
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      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  731 upvotes 3 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community How much do you guys think diet and sleep affects results?

      in Research/Science  36 upvotes 2 years ago
      The conversation discusses whether lifestyle factors like diet and sleep affect hair growth in people with reversible hair loss. Some believe these factors, along with treatments like minoxidil, finasteride, and RU58841, can improve hair health, while others argue hair loss is mostly determined by genetics and DHT sensitivity.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 3 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

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