Polymorphism of the Androgen Receptor Gene Is Associated with Male Pattern Baldness

The study found a significant association between male pattern baldness (MPB) and polymorphisms in the androgen receptor (AR) gene. Researchers observed that the StuI restriction site was present in 98.1% of young bald men and 92.3% of older bald men, compared to 76.6% of non-bald men, indicating a strong genetic link. Additionally, shorter CAG and GGC triplet repeats were more common in bald men. These findings suggested that these genetic markers were closely linked to a functional variant necessary for the polygenic determination of MPB, highlighting the complexity of MPB involving both genetic predispositions and androgen receptor activity.