Androgen Receptor Gene Polymorphisms and Risk for Androgenetic Alopecia: A Meta-Analysis

March 2012 in “ Clinical and Experimental Dermatology ”

F. L. Zhuo, Wei Xu, Lin Wang, Yanwen Wu, Z. Z. Xu, Jingzhou Zhao

androgen receptor gene polymorphisms androgenetic alopecia AGA G allele AR Stul polymorphism CAG triplet-repeat polymorphism GGC triplet-repeat polymorphism androgen receptor genetic variations male pattern baldness

TLDR G allele of AR Stul polymorphism linked to higher hair loss risk, especially in white people.

This meta-analysis examined the association between androgen receptor gene polymorphisms and androgenetic alopecia (AGA). The study found that the G allele of the AR Stul polymorphism may be a potential risk factor for AGA, especially in white populations. However, the CAG and GGC triplet-repeat polymorphisms of the AR gene did not have any obvious association with risk for AGA. The study suggests that further large studies with adequate methodological quality are necessary to obtain valid results.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities

126 citations, January 2010 in “British Journal of Dermatology”

Baldness is more common in Chinese men than women, increasing with age, and is influenced by genetics.

research Evaluation of Androgen Receptor Gene as a Candidate Gene in Female Androgenetic Alopecia

23 citations, May 2009 in “International Journal of Dermatology”

AR gene not major factor in female hair loss; different from male hair loss.

research Prevalence and Types of Androgenetic Alopecia in Shanghai, China: A Community-Based Study

66 citations, February 2009 in “British Journal of Dermatology”

Chinese men have lower AGA rates than Caucasians, with type III vertex most common; family history is important.

research EDA2R Is Associated With Androgenetic Alopecia

82 citations, September 2008 in “Journal of Investigative Dermatology”

EDA2R gene linked to hair loss.

research Association of Androgenetic Alopecia With Smoking and Its Prevalence Among Asian Men

91 citations, November 2007 in “Archives of Dermatology”

Smoking linked to hair loss in Asian men.

Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

research Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

60 citations, January 2007 in “Human Genetics”

AR polyglycine repeat doesn't cause baldness.

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations, July 2005 in “American Journal of Human Genetics”

Genetic variation in the androgen receptor gene mainly causes early-onset hair loss, with maternal inheritance playing a key role.

The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

76 citations, April 2005 in “Cancer Epidemiology, Biomarkers & Prevention”

E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

research Molecular Mechanisms of Androgenetic Alopecia

229 citations, August 2002 in “Experimental Gerontology”

AGA causes hair loss by shrinking hair follicles due to DHT binding, and can be treated with finasteride and minoxidil.

research The Prevalence and Types of Androgenetic Alopecia in Korean Men and Women

157 citations, July 2001 in “British Journal of Dermatology”

AGA more common in men, Koreans have lower rates and unique patterns.

research Incidence of Female Androgenetic Alopecia (Female Pattern Alopecia)

89 citations, January 2001 in “Dermatologic Surgery”

Hair loss in women is common, starts in late 20s, and affects 30% of women over 50.

Similar Research

5 / 1000+ results

Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

research Androgenetic Alopecia and Polymorphism of the Androgen Receptor Gene (SNP rs6152) in Patients with Benign Prostate Hyperplasia or Prostate Cancer

11 citations, January 2015 in “Journal of The European Academy of Dermatology and Venereology”

Hair loss gene linked to prostate issues.

A Genetic Test for Androgenetic Alopecia: Polymorphisms in the Androgen Receptor Gene Provide a Genetic Screening Test for Androgenetic Alopecia and Earlier Medical Intervention

research A Genetic Test for Androgenetic Alopecia: Polymorphisms in the Androgen Receptor Gene Provide a Genetic Screening Test for Androgenetic Alopecia and Earlier Medical Intervention

May 2008 in “Hair transplant forum international”

A genetic test can identify people at risk of male pattern baldness early, allowing for quicker treatment.

research Androgens and Androgen Receptor Action in Skin and Hair Follicles

100 citations, September 2017 in “Molecular and Cellular Endocrinology”

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

research Characteristics of Androgenetic Alopecia in Asian Populations

51 citations, January 2012 in “Annals of Dermatology”

Asian hair loss differs from Europeans; consider individual needs and psychological well-being for treatment.

research Androgenic Alopecia: Cross-Talk Between Cell Signal Transduction Pathways

1 citations, May 2017 in “InTech eBooks”

Hair loss in Androgenetic alopecia (AGA) is due to altered cell sensitivity to hormones, not increased hormone levels. Hair growth periods shorten over time, causing hair to become thinner and shorter. This is linked to miscommunication between cell pathways in hair follicles. There's also a change in gene expression related to blood vessels and cell growth in balding hair follicles. The exact molecular causes of AGA are still unclear.