Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

January 2007 in “ Human Genetics ”

Justine A. Ellis, Katrina J Scurrah, J Cobb, Sophie Zaloumis, Anna Kathryn Duncan, Stephen B. Harrap

androgen receptor AR polyglycine repeat polymorphism androgenetic alopecia AGA non-coding sequence male pattern baldness AR

TLDR AR polyglycine repeat doesn't cause baldness.

This 2007 study investigated the relationship between baldness and the androgen receptor (AR) polyglycine repeat polymorphism. The study found that the AR polyglycine repeat polymorphism does not confer susceptibility to androgenetic alopecia (AGA), and that other variations in or around AR may be contributing to the phenotype of AGA. The study suggests that further analysis and understanding of the importance of non-coding sequence in this region is required in order to identify variation that may be functionally relevant to the heritability of male pattern baldness.

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Research cited in this study

3 / 3 results

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

195 citations, July 2005 in “American Journal of Human Genetics”

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research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

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E211 G>A gene linked to lower risk of severe prostate cancer and hair loss.

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Men can report their own balding patterns well enough for large health studies.

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Baldness And The Androgen Receptor: The AR Polyglycine Repeat Polymorphism Does Not Confer Susceptibility To Androgenetic Alopecia

Research cited in this study

research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

research The E211 G>A Androgen Receptor Polymorphism Is Associated With a Decreased Risk of Metastatic Prostate Cancer and Androgenetic Alopecia

research Validity of Self-Reported Male Balding Patterns in Epidemiological Studies

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