Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case-Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk

    January 2025 in “ Nutrients
    Roberto Ambra, Simona Mastroeni, Sonia Manca, Thomas J. Mannooranparampil, Fabio Virgili, Barbara Marzani, Daniela Pinto, Cristina Fortes
    Image of study
    TLDR Genetic factors and diet significantly increase the risk of male pattern baldness.
    This study examined the role of genetic variants and lifestyle factors in androgenetic alopecia (AGA) among 212 male subjects, including 104 affected individuals and 108 controls. It identified specific single nucleotide polymorphisms (SNPs), such as the TT genotype of rs1041668 and allele A of rs1160312 and rs6113491, as significantly associated with an increased risk of AGA, with odds ratios of 4.47, 2.97, and 2.99, respectively. Additionally, lifestyle factors like diet, family history, and body mass index (BMI) were significant contributors to AGA risk, while smoking was not. The study underscores the multifactorial nature of AGA, suggesting that both genetic predispositions and dietary habits play crucial roles in its development.
    Discuss this study in the Community →

    Research cited in this study

    28 / 28 results

    Related Community Posts Join

    6 / 1000+ results

      community Dutasteride Literally Saves Your Hair

      in Finasteride/Dutasteride  100 upvotes 8 months ago
      Dutasteride significantly reduces scalp DHT levels and can save hair, though shedding is part of the process. Some users report success with dutasteride, while others struggle despite using it along with finasteride and oral minoxidil.

      community Why does it seem everyone favors finasteride over dutasteride?

      in Female  62 upvotes 9 months ago
      The conversation discusses preferences for hair loss treatments, specifically finasteride over dutasteride. Users share personal experiences, cost considerations, FDA approval status, and potential side effects, with some switching between treatments to find what works best for them.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  41 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Similar Research

    5 / 1000+ results