Genetic Variants and Lifestyle Factors in Androgenetic Alopecia Patients: A Case-Control Study of Single Nucleotide Polymorphisms and Their Contribution to Baldness Risk

    January 2025 in “ Nutrients
    Roberto Ambra, Simona Mastroeni, Sonia Manca, Thomas J. Mannooranparampil, Fabio Virgili, Barbara Marzani, Daniela Pinto, Cristina Fortes
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    TLDR Genetic factors and diet significantly increase the risk of male pattern baldness.
    This study examined the role of genetic variants and lifestyle factors in androgenetic alopecia (AGA) among 212 male subjects, including 104 affected individuals and 108 controls. It identified specific single nucleotide polymorphisms (SNPs), such as the TT genotype of rs1041668 and allele A of rs1160312 and rs6113491, as significantly associated with an increased risk of AGA, with odds ratios of 4.47, 2.97, and 2.99, respectively. Additionally, lifestyle factors like diet, family history, and body mass index (BMI) were significant contributors to AGA risk, while smoking was not. The study underscores the multifactorial nature of AGA, suggesting that both genetic predispositions and dietary habits play crucial roles in its development.
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