26-SNP Panel Aids Guiding Androgenetic Alopecia Therapy and Provides Insight into Mechanisms of Action

    September 2025 in “ Cosmetics
    Hannah Gaboardi, Valentina Russo, Laura Vila-Vecilla, Vishal Patel, Gustavo Torres De Souza
    TLDR Genetic profiling can improve androgenetic alopecia treatment by predicting drug response and minimizing side effects.
    This study evaluated a 26-SNP pharmacogenetic panel's effectiveness in guiding androgenetic alopecia (AGA) treatment in 252 individuals, showing high response rates (85.6–91.0%) for minoxidil, finasteride, and dutasteride. Key findings include SNP rs1042028 in SULT1A1 as a predictor of poor response to all three drugs and the TT genotype of rs39848 in SRD5A1 linked to reduced efficacy of dutasteride. The study suggests that genetic profiling can optimize therapy by predicting efficacy and minimizing side effects, supporting a shift towards precision medicine in AGA treatment. Despite the promising results, further prospective studies are needed to validate these findings.
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