Activation of Cytoprotective Prostaglandin Synthase-1 by Minoxidil as a Possible Explanation for Its Hair Growth-Stimulating Effect

February 1997 in “ Journal of Investigative Dermatology ”

Jean-François Michelet, Stephane Commo, Nelly Billoni, Yann Mahe, Bruno Bernard

minoxidil prostaglandin synthase-1 PGHS-1 hair growth-stimulating effect cytoprotective homeostasis second-generation hair growth-promoting drugs Rogaine

TLDR Minoxidil boosts hair growth by activating PGHS-1.

This document explores the possible mechanism behind minoxidil's hair growth-stimulating effect. The study found that minoxidil activates cytoprotective prostaglandin synthase-1 (PGHS-1), which is essential for the homeostasis of mammalian cells. The activation of PGHS-1 by minoxidil could be a possible explanation for its hair growth-stimulating effect. The study suggests that more potent second-generation hair growth-promoting drugs might be designed based on this mechanism.

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