HIF-1α Stimulators Function Equally to Leading Hair Loss Agents in Enhancing Dermal Papilla Growth

January 2020 in “ Skin Pharmacology and Physiology ”

J. Bukowiecki, Dominik Pförringer, Dominik Thor, Dominik Duscher, Elizabeth A. Brett

hypoxia-inducible factor-1a HIF-1a deferiprone DFP minoxidil caffeine dermal papilla cells DPCs 3D spheroid culture model Rogaine

TLDR HIF-1α stimulators, like deferiprone, work as well as popular hair loss treatments, minoxidil and caffeine, in promoting hair growth.

In 2019, a study found that hypoxia-inducible factor-1a (HIF-1a) stimulating agents, specifically deferiprone (DFP), were as effective as popular hair loss treatments, minoxidil and caffeine, in promoting the growth of dermal papilla cells (DPCs), which are essential for hair growth and regeneration. The study used a 3D spheroid culture model to simulate the in vivo environment of DPCs. The results showed that DPC proliferation was significantly enhanced by caffeine, minoxidil, and DFP compared to the control group, with the highest proliferation seen in the DFP-treated group. The study suggested that HIF-1a stimulating agents could potentially serve as water-soluble alternatives to minoxidil in treating hair loss.

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