354 citations
,
February 2011 in “Genes & Development” This study found that abolishing H3K27me3 in mouse skin by targeting Ezh2 and Ezh1 affects hair follicle development and epidermal behavior, revealing functional differences between these tissues.
294 citations
,
February 2011 in “Cell” Nephronectin helps attach muscle cells to hair follicles.
116 citations
,
August 2010 in “Nature” Scientists turned rat thymus cells into stem cells that can help repair skin and hair.
43 citations
,
April 2010 in “Developmental Biology” In this study, researchers observed that the sebaceous gland niche in mice allows for Wnt-induced hair follicle differentiation, unlike the non-permissive bulge.
314 citations
,
April 2010 in “Developmental Cell” This study found that in mice, inactivating beta-catenin in the dermal papilla reduces hair follicle progenitor proliferation and disrupts the hair cycle.
351 citations
,
February 2010 in “Nature Cell Biology” Basal cell carcinoma mostly starts from cells in the upper skin layers, not hair follicle stem cells.
49 citations
,
October 2009 in “Cancer research” This study found that disrupting Stat3 in keratinocyte stem cells of mice reduced skin tumor formation by approximately 80%, suggesting Stat3's role in tumor initiation survival mechanisms.
503 citations
,
May 2009 in “Cell stem cell” This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.
36 citations
,
March 2009 in “Molecular Carcinogenesis” This study found that Bcl-xL deficiency in mice increased apoptosis and resistance to skin tumor development, highlighting Bcl-xL's role in early skin carcinogenesis through anti-apoptotic functions.
835 citations
,
October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
61 citations
,
September 2008 in “Stem Cells” This study found that DNA strand segregation in multipotent hair follicle stem cells occurs randomly during development and tissue homeostasis, challenging the immortal strand hypothesis.
193 citations
,
May 2008 in “Development” This study found that activating β-catenin signaling in embryonic epidermis promoted hair follicle characteristics at the expense of normal epidermal differentiation, leading to early pigmentation and innervation.
253 citations
,
April 2008 in “Current opinion in cell biology” This study found that Notch signalling promotes differentiation of epidermal cells and acts as a tumour suppressor in the skin by interacting with various pathways and mechanisms.
415 citations
,
January 2008 in “Cell” NFATc1 controls hair stem cell activity, affecting hair growth and could be a target for hair loss treatments.
153 citations
,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
688 citations
,
June 2007 in “Cell Stem Cell” This study found that deleting the ATR gene in adult mice led to rapid onset of age-related traits such as hair graying and osteoporosis through reduced regenerative capacity.
141 citations
,
May 2007 in “Cancer Research” This study found that CD34 is necessary for TPA-induced activation of hair follicle stem cells and tumor formation in mice, with CD34 knockout mice showing delayed and reduced tumor development compared to wild-types.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
207 citations
,
July 2006 in “Development” This study identified a novel MTS24-positive murine keratinocyte population with increased colony-forming ability, suggesting these cells may serve as a new reservoir of proliferative progenitor or stem cells in hair follicles.
176 citations
,
February 2006 in “Cancer Research” This study found that loss of Ptch1 function in mouse skin's basal cells is sufficient to rapidly induce tumors resembling human basal cell carcinoma, suggesting Ptch1 as a key tumor suppressor.
1279 citations
,
November 2005 in “Nature Medicine” 
291 citations
,
October 2005 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that rat whisker follicle stem cells can be expanded in culture and transplanted to form functional hair follicles, demonstrating their multipotency and potential for regenerative medicine.
113 citations
,
September 2005 in “Journal of Investigative Dermatology” This study found that a topical hedgehog agonist can stimulate hair growth by promoting the transition from the resting to growth phase of the hair cycle in adult mouse skin.
417 citations
,
September 2005 in “PLoS biology” This study developed molecular signatures for dermal papilla cells and their niche, uncovering novel signaling regulators and genes linked to hair disorders, which may inform future hair development research.
384 citations
,
June 2005 in “Genes & development” This study found that stabilized beta-catenin is crucial for activating stem cell transition from quiescence to proliferation in hair follicles by influencing gene expression within the stem cell niche.
335 citations
,
March 2004 in “Development” This study found that continuous β-catenin signaling in adult mouse epidermis can reprogram hair follicles to form benign tumors, which regress after the signaling is discontinued.
250 citations
,
November 2003 in “The Journal of Cell Biology” This study found that BMP receptor IA is crucial for hair progenitor cell differentiation in mice, and its sequential inhibition and activation are necessary to generate a functioning hair shaft.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
949 citations
,
January 2001 in “Cell” This study demonstrated that multipotent stem cells in adult mice whisker follicles migrate to produce whisker growth, and that this process requires precise control of stem cell trafficking.
194 citations
,
May 2000 in “Journal of Investigative Dermatology” This study demonstrated that blocking the Sonic hedgehog signaling pathway in mice led to reversible inhibition of body coat hair morphogenesis, while whisker development was unaffected.
231 citations
,
October 1999 in “Journal of Clinical Investigation” This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.
153 citations
,
April 1998 in “Current Biology” This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.
638 citations
,
October 1997 in “Nature” 745 citations
,
February 1992 in “Trends in genetics” This article describes the potential role of various growth factors and molecules in regulating mammalian hair follicle development but does not present new experimental results.
