The Malignant Capacity of Skin Tumors Induced by Expression of a Mutant H-Ras Transgene Depends on the Cell Type Targeted

    April 1998 in “ Current Biology ”
    Ken Brown, Douglas Strathdee, Sheila Bryson … Allan Balmain
    Studysummary This study found that benign tumors with a high risk of malignant progression primarily arise from hair follicle cells when a mutant ras gene is expressed in a specific population of epidermal cells in mice.
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    Research cited in this study 5

    1. Ornithine Decarboxylase Overexpression Is a Sufficient Condition for Tumor Promotion in Mouse Skin PubMed · 1997
    2. Skin Cancer: Mechanisms and Human Relevance Medical Entomology and Zoology · 1994
    3. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and in Transgenic Mice Molecular and Cellular Biology · 1993
    4. Probing Keratinocyte and Differentiation Specificity of the Human K5 Promoter In Vitro and In Transgenic Mice Molecular and Cellular Biology · 1993
    5. Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation The Journal of Cell Biology · 1993

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    1. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    2. Keratins of the Human Hair Follicle International review of cytology · 2005
    3. Hair Follicle Differentiation And Regulation The International Journal of Developmental Biology · 2004
    4. Hair Keratin Pattern in Human Hair Follicles Grown In Vitro Experimental dermatology · 2003