Skin-Specific Expression of a Truncated E1a Oncoprotein Binding to p105-Rb Leads to Abnormal Hair Follicle Maturation Without Increased Epidermal Proliferation

June 1993 in “ The Journal of Cell Biology ”

Caterina Missero, Carlos Serra, Kurt S. Stenn, G. Paolo Dotto

hair follicle maturation inner root sheath keratinocytes growth inhibitors Adenovirus E1a oncoprotein p105-Rb

Studysummary This study found that transgenic mice expressing a mutant E1a oncoprotein in their skin had disturbed hair follicle maturation but did not show increased tumor development or proliferation.

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