Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle

    April 2001 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Jonathan J Bull, Sven Mïller-Röver, Shyam A. Patel, Catherine M T Chronnell, Ian McKay, Michael P. Philpott
    TLDR Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
    The study investigated the expression patterns of Myc superfamily transcription factors (c-Myc, N-Myc, Max, Mad1, and Mad3) in human hair follicles during different stages of the hair growth cycle using immunohistochemistry. It found that c-Myc had distinct localization patterns, particularly in the bulge region of the outer root sheath, which is associated with the hair follicle stem cell compartment, and its expression was independent of the hair growth cycle stage. In contrast, N-Myc, Max, Mad1, and Mad3 were uniformly distributed across all epithelial layers in both anagen and telogen follicles. The study suggested that these transcription factors have different roles in various epithelial compartments of the hair follicle, potentially influencing cell fate within the stem cell compartment. Further investigation was needed to confirm these findings.
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