TLDR Different Myc family proteins are located in various parts of the hair follicle and may affect stem cell behavior.
The study investigated the expression patterns of Myc superfamily transcription factors (c-Myc, N-Myc, Max, Mad1, and Mad3) in human hair follicles during different stages of the hair growth cycle using immunohistochemistry. It found that c-Myc had distinct localization patterns, particularly in the bulge region of the outer root sheath, which is associated with the hair follicle stem cell compartment, and its expression was independent of the hair growth cycle stage. In contrast, N-Myc, Max, Mad1, and Mad3 were uniformly distributed across all epithelial layers in both anagen and telogen follicles. The study suggested that these transcription factors have different roles in various epithelial compartments of the hair follicle, potentially influencing cell fate within the stem cell compartment. Further investigation was needed to confirm these findings.
1113 citations
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
467 citations
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May 1999 in “Molecular Cell” Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.
5 citations
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January 2009 in “Dermato-endocrinology” ADAM 10 and ADAM 12 proteins are involved in different stages of hair growth and could be targets for treating hair disorders.
95 citations
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July 2006 in “British Journal of Dermatology” 154 citations
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October 1996 in “Proceedings of the National Academy of Sciences of the United States of America” Estrogen affects hair growth and skin cell multiplication.
21 citations
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December 1994 in “British Journal of Dermatology” The study investigated the potential of sheep vibrissa dermal papillae to induce hair follicle formation in skin equivalents. Researchers combined keratinocytes and other cells with a collagen matrix and fibroblasts, grafting these onto host animals. While initial grafts showed no cutaneous appendages, incorporating ovine dermal papillae led to the formation of follicle-like structures when grafted onto nude mice. These structures, although not fully compatible with normal follicle formation, displayed many in vivo follicle characteristics, including keratinized hair production. The findings suggested that skin equivalents could serve as a valuable model for studying the factors that promote hair follicle development.
