NG2 Proteoglycan Expression in Mouse Skin: Altered Postnatal Skin Development in the NG2 Null Mouse

November 2007 in “ Journal of Histochemistry & Cytochemistry ”

Kuniko Kadoya, Jun‐ichi Fukushi, Yoshihiro Matsumoto, Yu Yamaguchi, William B. Stallcup

TLDR NG2 is crucial for normal skin and hair development in mice.

The study investigated the role of NG2 proteoglycan in mouse skin development, revealing its expression in various skin layers and its prominence in hair follicle stem cells. In NG2 null mice, postnatal skin development was altered, with the epidermis failing to reach full thickness due to reduced basal keratinocyte proliferation, and delayed thickening of the subcutis caused by adipocyte deficiencies. These findings highlighted the importance of NG2 in normal skin and hair follicle development.

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