Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis

August 2000 in “ Cell ”

Gina Taylor, Michael S. Lehrer, Pamela J. Jensen, Tung Tien Sun, Robert M. Lavker

hair follicular stem cells bulge region upper follicular cells keratinocytes epidermis bipotent hair follicle

TLDR Hair follicle stem cells can form both hair follicles and skin.

The study from August 2000 demonstrated that follicular stem cells in the bulge region of hair follicles were bipotent, contributing to both hair follicle and epidermis formation. Using double-labeling techniques, researchers observed that upper follicular keratinocytes migrated into the epidermis in both newborn and adult mice, especially during wound repair. This indicated that hair follicles were a significant source of keratinocyte stem cells, highlighting their role in skin regeneration and the potential origin of certain skin tumors. The findings suggested that these stem cells could be crucial for skin repair and maintenance, with implications for therapeutic applications.

View this study on cell.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Urokinase Is a Positive Regulator of Epidermal Proliferation In Vivo

28 citations , February 1999 in “Journal of Investigative Dermatology”

Urokinase, a type of protein, helps skin cells multiply faster, especially in newborn mice.

Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

research Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles

130 citations , January 1994 in “Differentiation”

Mouse hair follicle cells briefly grow during the early hair growth phase, showing that these cells are important for starting the hair cycle.

research The Secret Life of the Hair Follicle

745 citations , February 1992 in “Trends in genetics”

Hair follicles create different cell layers and proteins, controlled by various molecules.

Related Community Posts Join

6 / 1000+ results

community DHT Harms Scalp Microbiome: DHT Itch is REAL

in Research/Science 413 upvotes 10 months ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 1 year ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community PP405 Won’t Work: Follicle Is Miniaturized, Fibrosed, And Missing Key Support Cells

in Research/Science 1 week ago

PP405 is ineffective for miniaturized, fibrosed hair follicles in androgenetic alopecia. AMP303 may activate hair follicle stem cells, but minoxidil and finasteride are still the main treatments.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community 30-Min Dermatology Visit – Best Questions to Ask About Balding? ( 175$ )

in Treatment 6 upvotes 11 months ago

The conversation discusses hair loss treatments, focusing on finasteride, minoxidil, and other options like PRP and ketoconazole. It highlights the importance of asking specific questions during a dermatology visit to determine the cause of hair loss and appropriate treatments.

community A Theory on Why Microneedling Works

170 upvotes 6 years ago

Microneedling may enhance hair regrowth by transferring stem cells to dormant follicles, improving the effects of minoxidil. Users discuss using microneedling with needle lengths around 1.5mm to stimulate hair growth.

Similar Research

5 / 1000+ results

Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

research Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

28 citations , February 2014 in “PLoS ONE”

Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.

research Hair Follicles and Their Role in Skin Health

16 citations , December 2006 in “Expert Review of Dermatology”

Hair follicles are essential for skin health, aiding in hair growth, wound healing, and immune function.

research Functional Hair Follicle Regeneration

January 2017 in “Springer eBooks”

Scientists made working hair follicles using stem cells, helping future hair loss treatments.

Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

research Secretory Phospholipase A2-IIA Overexpressing Mice Exhibit Cyclic Alopecia Mediated Through Aberrant Hair Shaft Differentiation and Impaired Wound Healing Response

7 citations , September 2017 in “Scientific Reports”

Mice with too much sPLA₂-IIA have hair loss and poor wound healing due to abnormal hair growth and stem cell depletion.

research Regeneration of Skin Appendages and Nerves: Current Status and Further Challenges

71 citations , February 2020 in “Journal of Translational Medicine”

Progress has been made in skin and nerve regeneration, but more research is needed to improve methods and ensure safety.