Thymosin Beta 4 Increases Hair Growth by Activation of Hair Follicle Stem Cells

    December 2003 in “ The FASEB Journal ”
    Deborah Philp, Mychi Nguyen, Brooke Scheremeta … Michael Elkin
    Studysummary In this study, thymosin beta4 was found to stimulate hair growth in normal rats and mice by affecting key processes in the hair follicle cycle, such as stem cell migration and extracellular matrix remodeling.
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    Research cited in this study 12

    1. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    2. Hepatocyte Growth Factor Activator Expressed in Hair Follicles Is Involved in In Vitro HGF-Dependent Hair Follicle Elongation Journal of Dermatological Science · 2001
    3. Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells Cell · 2001
    4. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    5. Basement Membrane Zone Remodeling During Appendageal Development in Human Fetal Skin: The Absence of Type VII Collagen Is Associated with Gelatinase-A (MMP2) Activity Journal of Investigative Dermatology · 2000
    6. Hair Cycle-Dependent Expression of Hepatocyte Growth Factor Activator, Other Proteinases, and Proteinase Inhibitors Correlates with the Expression of Hepatocyte Growth Factor in Rat Hair Follicles Journal of Investigative Dermatology Symposium Proceedings · 1999
    7. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    8. Hair Regrowth Dermatologic Clinics · 1998
    9. Immortalized Rat Whisker Dermal Papilla Cells Cooperate with Mouse Immature Hair Follicle Buds to Activate Type IV Procollagenases in Collagen Matrix Coculture: Correlation with Ability to Promote Hair Follicle Development in Nude Mouse Grafts Journal of Investigative Dermatology · 1995
    10. Cells Within the Bulge Region of Mouse Hair Follicle Transiently Proliferate During Early Anagen: Heterogeneity and Functional Differences of Various Hair Cycles Differentiation · 1994
    11. Growth Factors Specifically Alter Hair Follicle Cell Proliferation and Collagenolytic Activity Alone or in Combination Differentiation · 1990
    12. Epithelial Growth by Rat Vibrissae Follicles In Vitro Requires Mesenchymal Contact via Native Extracellular Matrix Journal of Investigative Dermatology · 1990

    Related research 6

    1. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    2. Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle Experimental and Therapeutic Medicine · 2016
    3. Hair Cycle Resting Phase Is Regulated by Cyclic Epithelial FGF18 Signaling Journal of Investigative Dermatology · 2012
    4. Hair Follicle Expression of 1,25-Dihydroxyvitamin D3 Receptors During the Murine Hair Cycle British Journal of Dermatology · 2006
    5. Biology of the Hair Follicle: The Basics Seminars in Cutaneous Medicine and Surgery · 2006
    6. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000