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GlossaryMatrix Metalloproteinase-2 (MMP-2)

enzyme that breaks down proteins in the extracellular matrix

Matrix Metalloproteinase-2 (MMP-2), also known as Gelatinase A, is an enzyme that breaks down proteins in the extracellular matrix, particularly type IV collagen. This process is crucial for tissue remodeling, wound healing, and angiogenesis, but excessive MMP-2 activity can contribute to diseases like cancer and fibrosis by promoting abnormal tissue degradation.

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research Wound Healing Effect of Supercritical Carbon Dioxide Datura Metel L. Leaves Extracts: An In Vitro Study of Anti-Inflammation, Cell Migration, MMP-2 Inhibition, and the Modulation of the Sonic Hedgehog Pathway in Human Fibroblasts

6 citations , July 2023 in “Plants”

Datura metel leaf extracts help heal wounds effectively.

research Effects of Yiqi Huayu Chinese Medicine on the Expression of MMP-2/TIMP-2 in BPH Rats

January 2011 in “Zhonghua zhongyiyao xuekan”

Yiqi Huayu medicine can effectively reduce BPH in rats by lowering MMP-2 levels and blood vessel growth.

research Matrix Remodelling and MMP Expression/Activation Are Associated with Hidradenitis Suppurativa Skin Inflammation

51 citations , March 2019 in “Experimental Dermatology”

Matrix changes and increased MMPs contribute to skin inflammation in hidradenitis suppurativa.

research Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle

21 citations , May 2016 in “Experimental and Therapeutic Medicine”

MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.

research Prevalence of MMP-1 rs1799750 Polymorphism in Androgenetic Alopecia: A Cross-Sectional Study in an Indonesian Population

November 2025 in “Molecular and Cellular Biomedical Sciences”

There is no significant link between the MMP-1 rs1799750 polymorphism and androgenetic alopecia in the Indonesian population.

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community Doubts about my new exosomes treatment

in Treatment 6 upvotes 4 months ago

A 22-year-old is frustrated with ongoing hair loss despite using treatments like topical minoxidil, finasteride, microneedling, oral dutasteride, and oral minoxidil. Their dermatologist suggests treating scalp inflammation with oral tretinoin and using exosomes for alopecia.

community Dudasteride/Minoxidil for 3 years. Anything else?

in Finasteride/Dutasteride 1 upvotes 4 months ago

The user has been using dutasteride and oral minoxidil for over three years with good results and is seeking additional treatments to improve hair growth by 10-15%. Suggestions include derma stamping, red light therapy, deep massage, caffeinated shampoos, and biotin supplementation.

community Why is my dermatologist strictly against derma stamping/derma rolling?

in Microneedling 27 upvotes 6 months ago

Dermatologists often advise against at-home microneedling due to risks of scarring, infection, and improper technique. Professional guidance is recommended for safe and effective use, with some users reporting positive results when done correctly.