Expression of Matrix Metalloproteinases and Tissue Inhibitor of Matrix Metalloproteinases in the Hair Cycle

    May 2016 in “ Experimental and Therapeutic Medicine ”
    Chun Hou, Yong Miao, Xue Wang, Chaoyue Chen, Bojie Lin, Zhiqi Hu
    TLDR MMP-2 and MMP-9 help hair grow, while their inhibitors peak when hair growth slows.
    The study examined the expression of matrix metalloproteinases (MMP-2 and MMP-9) and their inhibitors (TIMP-1 and TIMP-2) during the hair cycle in mice. It found that MMP-2 and MMP-9 had increased expression during the anagen phase, which decreased in the catagen and telogen phases, while TIMP-1 and TIMP-2 showed opposite patterns, peaking in the telogen phase. MMP-2 and TIMP-2 were present in all hair follicle structures, whereas MMP-9 and TIMP-1 were localized to specific areas. The study suggested that MMP-2 and MMP-9 played significant roles in the hair growth cycle, with MMP-2 potentially compensating for MMP-9 in hair canal formation, but further research was needed to fully understand these mechanisms.
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