Mouse Hair Cycle Expression Dynamics Modeled as Coupled Mesenchymal and Epithelial Oscillators

    November 2014 in “ PLOS Computational Biology ”
    Ryan Tasseff, Anjali Bheda-Malge, Teresa DiColandrea, Charles C. Bascom, Robert J. Isfort, Richard Gelinas
    Image of study
    TLDR The study concluded that hair growth in mice is regulated by a stable interaction between skin cell types, and disrupting this can cause hair loss.
    In the 2014 study, researchers developed a mathematical model to understand the dynamics of hair growth in mice by analyzing gene expression data. They identified 4627 probesets (3567 unique genes) with significant periodic expression patterns that may relate to hair cycle regulation. The model suggested that inhibitory regulation between expanding epithelial and background mesenchymal cells maintains synchronization, and only one configuration of positive-negative coupling was found to be dynamically stable. Bifurcation analysis indicated that impairing this negative regulation could lead to a pathological state resembling hair miniaturization. The study also associated specific gene clusters with mesenchymal populations and rapidly expanding follicular epithelial cells, supported by RNA and protein imaging for representative genes. This research provided insights into the synchronization mechanism between epithelial and mesenchymal populations in the hair cycle and identified potential mediators of this regulation.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results

      community Results of Procyanidin B2 in clinical studies

      in Treatment  13 upvotes 4 years ago
      Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  138 upvotes 9 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community Why is dht bad for scalp hair but good for hair on the rest of body?

      in Satire  109 upvotes 1 year ago
      The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

      community What's your option on complementary treatment

      in Product  3 upvotes 5 months ago
      The conversation discusses complementary treatments for hair loss while using finasteride and minoxidil, including scalp massagers, scrubs, coconut oil, and vitamin supplements. The user seeks opinions on these additional treatments.

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

    Similar Research

    5 / 1000+ results