Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis

    July 2010 in “ Genes & development ”
    Bing Hu, Karine Lefort, Wenying Qiu … G. Paolo Dotto
    Studysummary In this study, the researchers reported that Notch/CSL signaling is crucial for hair follicle differentiation, with Wnt5a signaling and FoxN1 acting as mediators in mice.
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    Research cited in this study 7

    1. Sox2-Positive Dermal Papilla Cells Specify Hair Follicle Type in Mammalian Epidermis Development · 2009
    2. Epidermal Notch Signaling: Differentiation, Cancer, and Adhesion Current opinion in cell biology · 2008
    3. Phospholipase C-δ1 Is an Essential Molecule Downstream of Foxn1, the Gene Responsible for the Nude Mutation, in Normal Hair Development The FASEB Journal · 2007
    4. Learning From Nudity: Lessons From The Nude Phenotype Experimental Dermatology · 2005
    5. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    6. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    7. Acidic and Basic Hair/Nail (Hard) Keratins: Their Colocalization in Upper Cortical and Cuticle Cells of the Human Hair Follicle and Their Relationship to Soft Keratins ˜The œjournal of cell biology/˜The œJournal of cell biology · 1986