Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

    January 2021 in “ Frontiers in cell and developmental biology ”
    Weiming Qiu, Pei-Rong Gu, Cheng‐Ming Chuong, Mingxing Lei
    Studysummary This paper discusses the multipotency of cyst cells and proposes that understanding molecular circuits in cyst formation could enable engineering of desired stem cell culture phenotypes, but reports no new experimental outcomes.
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    Research cited in this study 27

    1. Hair-Bearing Human Skin Generated Entirely From Pluripotent Stem Cells Nature · 2020
    2. PLCD1 and Pilar Cysts ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    3. Blimp1+ Cells Generate Functional Mouse Sebaceous Gland Organoids In Vitro Nature communications · 2019
    4. Hedgehog Stimulates Hair Follicle Neogenesis by Creating Inductive Dermis During Murine Skin Wound Healing Nature Communications · 2018
    5. Cutaneous Adnexal Cysts Revisited: What We Know and What We Think We Know Dermatopathology · 2018
    6. Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner Journal of Investigative Dermatology · 2018
    7. Temporal Layering of Signaling Effectors Drives Chromatin Remodeling During Hair Follicle Stem Cell Lineage Progression Cell stem cell · 2018
    8. Hair Follicle Development in Mouse Pluripotent Stem Cell-Derived Skin Organoids Cell Reports · 2018
    9. Getting to the Core of the Dermal Papilla Journal of Investigative Dermatology · 2017
    10. Self-Organization Process in Newborn Skin Organoid Formation Inspires Strategy to Restore Hair Regeneration of Adult Cells Proceedings of the National Academy of Sciences of the United States of America · 2017
    11. IL-1 Receptor Knockout Mice Develop Epidermal Cysts and Show an Altered Innate Immune Response After Exposure to UVB Radiation Journal of Investigative Dermatology · 2017
    12. Epidermal Stem Cells and Skin Tissue Engineering in Hair Follicle Regeneration World Journal of Stem Cells · 2015
    13. Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration Experimental Dermatology · 2014
    14. Disrupted Ectodermal Organ Morphogenesis in Mice with a Conditional Histone Deacetylase 1, 2 Deletion in the Epidermis Journal of Investigative Dermatology · 2013
    15. Therapeutic Strategy for Hair Regeneration: Hair Cycle Activation, Niche Environment Modulation, Wound-Induced Follicle Neogenesis, and Stem Cell Engineering Expert Opinion on Biological Therapy · 2013
    16. Tuning Wnt Signals for More or Fewer Hairs Journal of Investigative Dermatology · 2013
    17. Stress-Induced Production of Chemokines by Hair Follicles Regulates the Trafficking of Dendritic Cells in Skin Nature Immunology · 2012
    18. Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration Cell · 2011
    19. The Disintegrin/Metalloproteinase Adam10 Is Essential for Epidermal Integrity and Notch-Mediated Signaling Development · 2011
    20. Control of Hair Follicle Cell Fate by Underlying Mesenchyme Through a CSL–Wnt5a–FoxN1 Regulatory Axis Genes & development · 2010
    21. Genetic Interplays Between Msx2 And Foxn1 Are Required For Notch1 Expression And Hair Shaft Differentiation Developmental Biology · 2008
    22. Molecular Dissection of Mesenchymal–Epithelial Interactions in the Hair Follicle PLoS biology · 2005
    23. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    24. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    25. Phospholipase Cδ1 Is Required for Skin Stem Cell Lineage Commitment The EMBO Journal · 2003
    26. Regeneration of a New Hair Follicle from the Upper Half of a Human Hair Follicle in a Nude Mouse Journal of Investigative Dermatology · 2002
    27. Tcf3 and Lef1 Regulate Lineage Differentiation of Multipotent Stem Cells in Skin Genes & Development · 2001