Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

    January 2021 in “ Frontiers in cell and developmental biology ”
    Weiming Qiu, Pei-Rong Gu, Cheng‐Ming Chuong, Mingxing Lei
    TLDR Skin cysts might help advance stem cell treatments to repair skin.
    The 2021 study "Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures" discovered that skin cysts, previously thought to be a pathological dead-end, have the potential to contribute to the formation of new organs or tissues in organoid cultures. This finding could be significant for regenerative medicine and tissue engineering. The study also found that the deletion of β-catenin in basal epidermal and hair follicular keratinocytes led to epidermal hyperplasia and cyst formation. Additionally, the Notch signaling pathway was found to play a role in maintaining hair follicle and epidermis homeostasis, with specific deletion of Notch pathway genes resulting in skin cyst formation. The study concluded that cysts formed from progenitor/stem cells can maintain multipotency and regenerate original tissues under pathological and skin organoid culture conditions. However, the number of samples used in the study was not mentioned.
    Discuss this study in the Community →

    Research cited in this study

    21 / 21 results

    Related Community Posts Join

    6 / 1000+ results

      community C’est terrible - at my wits end

      in Female  443 upvotes 1 year ago
      A 29-year-old woman is experiencing gradual hair thinning since age 15, suspects Androgenic Alopecia, and has tried 5% minoxidil with little success. She has purchased various hair loss treatments including minoxidil, dutasteride, finasteride, and spironolactone, but is cautious about starting them due to potential interactions with her ADHD medication.

      community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

      in Female  56 upvotes 1 year ago
      A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

      community Verteporfin day 119 update - donor hair regeneration human trial

      in Research/Science  146 upvotes 2 years ago
      A human trial of verteporfin, a drug that can inhibit wound healing by scarring and promote regeneration of original tissue and hair follicles to provide an unlimited source for hair transplants; people discussed the potential of this drug and how it could be rolled out in mainstream with more doctors getting on board.

      community [25, F] [RANT] Shedding since March 2020. This just isn’t fair.

      in Female  42 upvotes 3 years ago
      User "missbloombastic" has been experiencing hair loss since 2016 and tried min, fin, multivitamins, and spiro with mixed results. Another user shares their struggle with hair loss and its impact on self-esteem, while a third user suggests checking blood tests and confirming the cause of hair loss.

    Similar Research

    5 / 1000+ results