Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures

    January 2021 in “ Frontiers in cell and developmental biology ”
    Weiming Qiu, Pei-Rong Gu, Cheng‐Ming Chuong, Mingxing Lei
    TLDR Skin cysts might help advance stem cell treatments to repair skin.
    The 2021 study "Skin Cyst: A Pathological Dead-End With a New Twist of Morphogenetic Potentials in Organoid Cultures" discovered that skin cysts, previously thought to be a pathological dead-end, have the potential to contribute to the formation of new organs or tissues in organoid cultures. This finding could be significant for regenerative medicine and tissue engineering. The study also found that the deletion of β-catenin in basal epidermal and hair follicular keratinocytes led to epidermal hyperplasia and cyst formation. Additionally, the Notch signaling pathway was found to play a role in maintaining hair follicle and epidermis homeostasis, with specific deletion of Notch pathway genes resulting in skin cyst formation. The study concluded that cysts formed from progenitor/stem cells can maintain multipotency and regenerate original tissues under pathological and skin organoid culture conditions. However, the number of samples used in the study was not mentioned.
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