Macrophages Promote Wound-Induced Hair Follicle Regeneration in a CX3CR1- and TGF-β1-Dependent Manner

    April 2018 in “ Journal of Investigative Dermatology ”
    Waleed Rahmani, Yunan Liu, Nicole L. Rosin, Adrienne Kline, Eko Raharjo, Jessica L. Yoon, Jo Anne Stratton, Sarthak Sinha, Jeff Biernaskie
    Image of study
    TLDR Macrophages help hair growth after injury through CX3CR1 and TGF-β1.
    This study found that macrophages play a crucial role in promoting hair follicle regeneration after a wound, in a manner dependent on the CX3CR1 receptor and TGF-β1. The researchers used a mouse model and found that depletion of macrophages led to reduced hair growth in the injured area. These findings suggest that targeting macrophages and their signaling pathways could be a potential therapeutic strategy for promoting hair growth in individuals with hair loss or alopecia.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    3 / 3 results

      community Verteporfin and Microneedling

      in Treatments 6 months ago
      Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

    Related Research

    6 / 6 results