Macrophages Induce AKT/β-Catenin-Dependent Lgr5+ Stem Cell Activation and Hair Follicle Regeneration Through TNF

    March 2017 in “ Nature Communications ”
    Xusheng Wang, Haiyan Chen, Rui-Yun Tian, Yiling Zhang, Marina S. Drutskaya, Chengmei Wang, Jian-Feng Ge, Zhimeng Fan, Deqiang Kong, Xiaoxiao Wang, Ting Cai, Ying Zhou, Jingwen Wang, Jin-Mei Wang, Shan X. Wang, Zhihai Qin, Huanhuan Jia, Yue Wu, Jia Liu, Sergei A. Nedospasov, Edward E. Tredget, Mei Lin, Jianjun Liu, Yuyang Jiang, Yaojiong Wu
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    TLDR Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.
    Macrophages play a crucial role in hair follicle regeneration by activating Lgr5+ stem cells through the AKT/β-catenin pathway and TNF. Targeting macrophages and TNF could be a potential therapeutic strategy for hair loss and alopecia. TNF is necessary for hair follicle regeneration and activates hair follicle stem cells through the AKT/β-catenin signaling pathway. The study used mice to observe these findings.
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