Principles and Mechanisms of Regeneration in the Mouse Model for Wound-Induced Hair Follicle Neogenesis
June 2015
in “
Regeneration
”
![Image of study](/images/research/b1454642-09fd-4e5d-ba37-951e65a3c0c4/medium/12195.jpg)
TLDR Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.
The document from June 9, 2015, explores wound-induced hair follicle neogenesis (WIHN) in mice, a process where new hair follicles regenerate de novo in the center of large skin wounds. It details how this regeneration does not stem from preexisting hair-fated bulge stem cells but may involve a blastema-like mechanism with epigenetic reprogramming of wound cells. The study emphasizes the role of WNT signaling, which is activated by Fgf9 signaling from γδ T cells, in this process. The document also notes the variability in hair follicle regeneration, including differences in pigmentation and orientation, and the use of WNT and BMP pathway reporters to visualize neogenic hairs. It concludes that WIHN is a valuable model for studying mammalian regeneration, with a need for further research to fully understand the cellular and signaling mechanisms involved.
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