TLDR Wnt-10b is important for starting hair growth and developing hair follicles.
The 2006 study concluded that Wnt-10b significantly contributes to hair follicle development and trichogenesis. It was found that recombinant Wnt-10b (rWnt-10b) accelerated hair follicle formation in cultured embryonic mouse skin and stimulated hair growth in reconstituted skin on nude mice. Hair follicle development was evident in embryonic skin treated with rWnt-10b after 2 days, and brown hair growth was observed in reconstituted skin on Balb/c nude mice when Wnt-10b-producing cells were included in the transplant. These findings indicate that Wnt-10b is essential for the initiation of hair follicle development and hair growth.
139 citations,
July 1991 in “Journal of The American Academy of Dermatology” Understanding hair follicle anatomy helps diagnose hair disorders.
65 citations,
October 1988 in “Clinics in dermatology” The dermal papilla interacts with the epidermis to control hair growth and development.
356 citations,
December 1986 in “The journal of cell biology/The Journal of cell biology” Hair and nail cells share similar proteins, indicating a common differentiation pathway.
12 citations,
August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
September 2016 in “Journal of Dermatological Science” Wnt-10b is important for keeping mouse skin cells healthy for hair growth.
26 citations,
July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
103 citations,
November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
314 citations,
April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
