TLDR Wnt-10b is important for starting hair growth and developing hair follicles.
The 2006 study concluded that Wnt-10b significantly contributes to hair follicle development and trichogenesis. It was found that recombinant Wnt-10b (rWnt-10b) accelerated hair follicle formation in cultured embryonic mouse skin and stimulated hair growth in reconstituted skin on nude mice. Hair follicle development was evident in embryonic skin treated with rWnt-10b after 2 days, and brown hair growth was observed in reconstituted skin on Balb/c nude mice when Wnt-10b-producing cells were included in the transplant. These findings indicate that Wnt-10b is essential for the initiation of hair follicle development and hair growth.
Cited in this study
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139 citations
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65 citations
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October 1988 in “Clinics in dermatology” The dermal papilla interacts with the epidermis to control hair growth and development.
356 citations
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December 1986 in “The journal of cell biology/The Journal of cell biology” Hair and nail cells share similar proteins, indicating a common differentiation pathway.
12 citations
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August 2020 in “Frontiers in Genetics” H19 boosts hair growth potential by activating Wnt signaling, possibly helping treat hair loss.
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26 citations
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July 2016 in “PLOS ONE” Activating β-catenin in certain skin cells speeds up hair growth in mice.
103 citations
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November 2014 in “Journal of Cell Biology” MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.