Dermal-Epidermal Interactions in Hair Follicle Development and Cycling

October 1988 in “ Clinics in dermatology ”

R. F. Oliver, Colin A.B. Jahoda

dermal papilla epidermis follicle development hair cycle anagen follicle morphogenesis epidermal proliferation papilla cells epidermal cell attachment proliferation intrapapillary cycle dermal component systemic factors follicle behavior

Studysummary This study found that dermal papilla cells may play a critical role in hair follicle development and cycling by promoting epidermal proliferation and potentially mediating systemic factors that influence follicle behavior.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research The In Vitro Properties of Dermal Papilla Cell Lines Established From Human Hair Follicles

106 citations , April 1986 in “British Journal of Dermatology”

This study found that dermal papilla cells from human hair follicles form multi-layered aggregates when cultured in vitro, contrasting with the monolayer growth of dermal fibroblasts.

research Inductive Capacity of Irradiated Dermal Papillae

30 citations , February 1977 in “Nature”

This study found that high doses of irradiation can cause permanent hair loss in rats by destroying the epithelial elements of the hair follicle, while leaving the dermal papilla intact and capable of inducing new hair growth upon transplantation.

research Modulation of Dermal Cell Activity During Hair Growth in the Rat

55 citations , February 1975 in “Journal of Cutaneous Pathology”

This study observed that during the rat hair cycle, DNA synthesis in dermal cells peaks during a specific growth stage, suggesting a coordinated metabolic activity with potential implications for alopecia areata research.