Dermal-Epidermal Interactions in Hair Follicle Development and Cycling

    October 1988 in “ Clinics in dermatology ”
    R. F. Oliver, Colin A.B. Jahoda
    TLDR The dermal papilla interacts with the epidermis to control hair growth and development.
    The document discussed the role of dermal-epidermal interactions in hair follicle development and cycling, emphasizing the importance of the dermal papilla. The dermal papilla, a stable population of specialized fibroblasts, interacted with the epidermis to ensure follicle development and continued to influence the follicular epidermis throughout the hair cycle. The study suggested that the papilla provided factors that stimulated epidermal proliferation, initiating and sustaining anagen and follicle morphogenesis. Additionally, the dermal component of the follicle mediated the influence of systemic factors, such as androgens, on hair growth. The findings indicated that understanding these interactions could reveal intrinsic control mechanisms regulating hair development and growth in both normal and disease states.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  42 upvotes 4 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

      community Vitamin C and hair growth PH levels

      in Product  31 upvotes 2 years ago
      The conversation is about using vitamin C and Magnesium L-Threonate for hair growth by reducing DHT binding to dermal papilla cells. The original post about vitamin C's pH levels and sebum control was possibly removed by a moderator.

      community Keratin microspheres - breakthrough

      in Research/Science  13 upvotes 9 months ago
      A gel of keratin microspheres promotes hair follicle growth, showing similar effectiveness to minoxidil in mice. The treatment activates hair growth pathways and reduces inflammation, with potential applications in drug delivery for hair-related disorders.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

    Related Research

    6 / 6 results