TGFβ Family Mimetic Peptide Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice

    August 2018 in “ Biomedical dermatology ”
    Youngkeun Choi, Soo Young Choi, Hyonmin Kim, Jeongmin Kim, Mun Sang Ki, In‐Sook An, Jae Yun Jung
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    Studysummary This study found that topical administration of the TGFβ mimetic peptide DPS-1 stimulated hair growth in mice by promoting HDP cell proliferation and enhancing hair follicle morphology.
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    In the 2018 study, researchers found that a TGFβ mimetic peptide, DPS-1, promoted the proliferation of human dermal papilla cells in 3D culture and stimulated hair growth in C57BL/6 mice. DPS-1 was shown to increase the expression of hair growth-related genes and activate the WNT/β-catenin signaling pathway. Topical application of DPS-1 on mice resulted in increased hair follicle size and depth compared to controls. The findings suggest DPS-1 as a potential treatment for hair loss, although the number of mice used was not specified. The evidence was based on three independent experiments.
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