Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling

The document from 2015 explores the function of GasderminA3 (Gsdma3) in hair follicle cycling, specifically in the transition from the regression phase (catagen) to the resting phase (telogen). The study found that Gsdma3 mutations in mice lead to an abnormal hair cycle where the hair follicles bypass the typical telogen phase and directly enter the growth phase (anagen), characterized by an epithelial strand-like structure (ESLS). This abnormal transition was associated with upregulated Wnt10b expression and increased cell proliferation due to decreased Gsdma3-mediated suppression of Wnt/ß-catenin signaling. Conversely, overexpression of Gsdma3 resulted in normal telogen entry and reduced Wnt signaling. The study suggests that Gsdma3 is crucial for normal hair follicle cycling by regulating Wnt signaling and that the typical telogen phase is not essential for initiating a new hair cycle. However, the number of mice used in the study was not specified, which is a limitation in assessing the study's strength.