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GlossaryGsdma3

gene involved in hair follicle development and skin health

Gsdma3 stands for Gasdermin A3, a gene that plays a crucial role in hair follicle development and skin health. Mutations in this gene can lead to hair loss (alopecia) and skin abnormalities, making it a significant focus in dermatological and genetic research.

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research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations , December 2011 in “American Journal Of Pathology”

A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.

research Gsdma3 Is Required for Hair Follicle Differentiation in Mice

30 citations , October 2010 in “Biochemical and biophysical research communications”

The Gsdma3 gene is essential for normal hair development in mice.

research In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Anti-Psoriatic Agents: Effects on Epidermal Thickness, as Determined by Optical Coherence Tomography and H&E Staining

15 citations , February 2011 in “Experimental Dermatology”

Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.

research Gsdma3 regulates hair follicle differentiation via Wnt5a-mediated non-canonical Wnt signaling pathway

11 citations , October 2017 in “Oncotarget”

Gsdma3 affects hair growth by controlling Wnt5a, which influences hair cell development.

research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice

11 citations , June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

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