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GlossaryGsdma3

gene involved in hair follicle development and skin health

Gsdma3 stands for Gasdermin A3, a gene that plays a crucial role in hair follicle development and skin health. Mutations in this gene can lead to hair loss (alopecia) and skin abnormalities, making it a significant focus in dermatological and genetic research.

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research Gsdma3 Mutation Causes Bulge Stem Cell Depletion and Alopecia Mediated by Skin Inflammation

54 citations, December 2011 in “American Journal Of Pathology”

A Gsdma3 mutation causes hair loss due to stem cell damage from skin inflammation.

research Gsdma3 Is Required for Hair Follicle Differentiation in Mice

30 citations, October 2010 in “Biochemical and biophysical research communications”

The Gsdma3 gene is essential for normal hair development in mice.

research In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Anti-Psoriatic Agents: Effects on Epidermal Thickness, as Determined by Optical Coherence Tomography and H&E Staining

15 citations, February 2011 in “Experimental Dermatology”

Betamethasone dipropionate reduced skin thickness, fish oil increased it, and combined treatment had no significant effect.

research Upregulation of Interfollicular Epidermal and Hair Infundibulum β-Catenin Expression in Gsdma3 Mutant Mice

11 citations, June 2012 in “Acta histochemica”

Mice with a Gsdma3 gene mutation have thicker skin and longer hair follicle openings due to increased β-catenin levels.

research In Vivo Response of GsdmA3Dfl/+ Mice to Topically Applied Fish Oil – Effects on Cellular Markers and Macrophages

1 citations, June 2016 in “FEBS open bio”

Fish oil increased cell growth and macrophages in the skin but didn't affect COX-2 expression.

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