Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

    July 2012 in “ Journal of Investigative Dermatology ”
    Yu Hong Li, Kun Zhang, Ke Yang … Feng Shen
    Studysummary The researchers observed that overexpression of Wnt10b in a mouse model can induce hair follicle regeneration by switching follicles from the resting phase to the growth phase via the Wnt-β-catenin signaling pathway.
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    Research cited in this study 10

    1. Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia Journal of Dermatological Science · 2012
    2. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    3. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011
    4. Self-Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells Science · 2011
    5. Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding Nature · 2007
    6. The Hair Cycle Journal of Cell Science · 2006
    7. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    8. Hairless Triggers Reactivation of Hair Growth by Promoting Wnt Signaling Proceedings of the National Academy of Sciences of the United States of America · 2005
    9. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    10. Basal Cell Carcinoma Possibly Originates From the Outer Root Sheath and/or the Bulge Region of the Vellus Hair Follicle Archives of Dermatological Research · 1999

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    4. Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration Journal of Investigative Dermatology · 2012
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    6. Beta-Catenin Activity in the Dermal Papilla Regulates Morphogenesis and Regeneration of Hair Developmental Cell · 2010
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