Adenovirus-Mediated Wnt10b Overexpression Induces Hair Follicle Regeneration

    July 2012 in “ Journal of Investigative Dermatology ”
    Yu Hong Li, Kun Zhang, Ke Yang, Jixing Ye, Yizhan Xing, Haiying Guo, Fang Ming Deng, Xiaohua Lian, Feng Shen
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    TLDR Wnt10b overexpression can regenerate hair follicles, possibly helping treat hair loss and alopecia.
    The study found that overexpression of Wnt10b can induce hair follicle regeneration in mice through the Wnt/ß-catenin signaling pathway. The induced hair follicles expressed structure markers and could cycle normally into catagen. The study provides insights into the regulation of hair follicle cycling and potential therapeutic targets for hair follicle-related diseases. Wnt10b may be a potential target for hair loss treatment and alopecia.
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